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Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 [ Mus musculus (house mouse) ]

Gene ID: 16206, updated on 12-Aug-2018

Summary

Official Symbol
Lrig1provided by MGI
Official Full Name
leucine-rich repeats and immunoglobulin-like domains 1provided by MGI
Primary source
MGI:MGI:107935
See related
Ensembl:ENSMUSG00000030029 Vega:OTTMUSG00000024528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Img; LIG-1; D6Bwg0781e
Expression
Ubiquitous expression in colon adult (RPKM 30.2), cerebellum adult (RPKM 20.8) and 26 other tissues See more
Orthologs

Genomic context

See Lrig1 in Genome Data Viewer
Location:
6 D2; 6 43.15 cM
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (94604529..94700253, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (94554523..94650139, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene microRNA 7041 Neighboring gene prefoldin 4 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
hair cycle process IMP
Inferred from Mutant Phenotype
more info
PubMed 
innervation IGI
Inferred from Genetic Interaction
more info
PubMed 
otolith morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeats and immunoglobulin-like domains protein 1
Names
integral membrane glycoprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355269.1NP_001342198.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330
    Conserved Domains (7) summary
    cd05763
    Location:618692
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:444492
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:78330
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam07679
    Location:695782
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:143166
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:385441
    LRR_8; Leucine rich repeat
    pfam13927
    Location:496583
    Ig_3; Immunoglobulin domain
  2. NM_008377.2NP_032403.2  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032403.2

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330, BF465831, CN699905, D78572
    Consensus CDS
    CCDS20380.1
    UniProtKB/Swiss-Prot
    P70193
    Related
    ENSMUSP00000098686.2, OTTMUSP00000029393, ENSMUST00000101126.2, OTTMUST00000060276
    Conserved Domains (8) summary
    cd05763
    Location:618692
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00408
    Location:709772
    IGc2; Immunoglobulin C-2 Type
    smart00082
    Location:444492
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:57325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:601691
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:143166
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:213273
    LRR_8; Leucine rich repeat
    pfam13927
    Location:496583
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    94604529..94700253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505621.2XP_006505684.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X1

    Conserved Domains (7) summary
    cd05763
    Location:618692
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:444492
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:78330
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam07679
    Location:695782
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:143166
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:385441
    LRR_8; Leucine rich repeat
    pfam13927
    Location:496583
    Ig_3; Immunoglobulin domain
  2. XM_006505622.2XP_006505685.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (9) summary
    cd05763
    Location:356430
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00408
    Location:447510
    IGc2; Immunoglobulin C-2 Type
    smart00082
    Location:182230
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:3156
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:339429
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:324
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:146179
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:123179
    LRR_8; Leucine rich repeat
    pfam13927
    Location:234321
    Ig_3; Immunoglobulin domain

RNA

  1. XR_377425.2 RNA Sequence

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