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Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 [ Mus musculus (house mouse) ]

Gene ID: 16206, updated on 31-Jan-2023

Summary

Official Symbol
Lrig1provided by MGI
Official Full Name
leucine-rich repeats and immunoglobulin-like domains 1provided by MGI
Primary source
MGI:MGI:107935
See related
Ensembl:ENSMUSG00000030029 AllianceGenome:MGI:107935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Img; LIG-1; D6Bwg0781e
Summary
Acts upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 30.2), cerebellum adult (RPKM 20.8) and 26 other tissues See more
Orthologs
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Genomic context

See Lrig1 in Genome Data Viewer
Location:
6 D2; 6 43.15 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (94581510..94677326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (94604529..94700298, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 Neighboring gene microRNA 7041 Neighboring gene VISTA enhancer mm1736 Neighboring gene VISTA enhancer mm878 Neighboring gene prefoldin 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within hair cycle process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innervation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within otolith morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeats and immunoglobulin-like domains protein 1
Names
integral membrane glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355269.2NP_001342198.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330
    Conserved Domains (7) summary
    cd05763
    Location:618692
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:444492
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:78330
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam07679
    Location:695782
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:143166
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:385441
    LRR_8; Leucine rich repeat
    pfam13927
    Location:496583
    Ig_3; Immunoglobulin domain
  2. NM_001410069.1NP_001396998.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330
  3. NM_001410070.1NP_001396999.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330
  4. NM_008377.3NP_032403.2  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032403.2

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330
    Consensus CDS
    CCDS20380.1
    UniProtKB/Swiss-Prot
    E9QL89, P70193
    Related
    ENSMUSP00000098686.3, ENSMUST00000101126.3
    Conserved Domains (8) summary
    cd05763
    Location:618692
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00408
    Location:709772
    IGc2; Immunoglobulin C-2 Type
    smart00082
    Location:444492
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:57325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:601691
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:143166
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:213273
    LRR_8; Leucine rich repeat
    pfam13927
    Location:496583
    Ig_3; Immunoglobulin domain

RNA

  1. NR_176936.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330
  2. NR_176937.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122272, AC155330

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    94581510..94677326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255196.2XP_030111056.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (6) summary
    cd05763
    Location:356430
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:182230
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:324
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:123179
    LRR_8; Leucine rich repeat
    pfam07679
    Location:433520
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:235335
    Ig; Immunoglobulin domain
  2. XM_030255195.1XP_030111055.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (6) summary
    cd05763
    Location:356430
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:182230
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:324
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:123179
    LRR_8; Leucine rich repeat
    pfam07679
    Location:433520
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:235335
    Ig; Immunoglobulin domain
  3. XM_006505622.3XP_006505685.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (6) summary
    cd05763
    Location:356430
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:182230
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:324
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:123179
    LRR_8; Leucine rich repeat
    pfam07679
    Location:433520
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:235335
    Ig; Immunoglobulin domain
  4. XM_030255198.1XP_030111058.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (6) summary
    cd05763
    Location:356430
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:182230
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:324
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:123179
    LRR_8; Leucine rich repeat
    pfam07679
    Location:433520
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:235335
    Ig; Immunoglobulin domain
  5. XM_036165882.1XP_036021775.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X1

    Conserved Domains (7) summary
    smart00082
    Location:339387
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:3861
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07679
    Location:590677
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:391478
    Ig_3; Immunoglobulin domain
    cd00096
    Location:598601
    Ig; Ig strand A' [structural motif]
    cd05763
    Location:497587
    IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
    cd21340
    Location:20220
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  6. XM_030255197.1XP_030111057.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (6) summary
    cd05763
    Location:356430
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:182230
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:324
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:123179
    LRR_8; Leucine rich repeat
    pfam07679
    Location:433520
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:235335
    Ig; Immunoglobulin domain

RNA

  1. XR_377425.4 RNA Sequence