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Il7r interleukin 7 receptor [ Mus musculus (house mouse) ]

Gene ID: 16197, updated on 21-Jan-2018
Official Symbol
Il7rprovided by MGI
Official Full Name
interleukin 7 receptorprovided by MGI
Primary source
MGI:MGI:96562
See related
Ensembl:ENSMUSG00000003882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD127; IL-7Ralpha
Summary
Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen adult (RPKM 3.1), thymus adult (RPKM 2.6) and 8 other tissues See more
Orthologs
Location:
15 A1; 15 4.16 cM
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (9506159..9529935, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (9435914..9459631, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferases 3 family, polypeptide A1 pseudogene Neighboring gene calcyphosine-like Neighboring gene sperm flagellar 2 Neighboring gene predicted gene, 41268 Neighboring gene prolactin receptor

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
    Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-7 Signaling Pathway, organism-specific biosystem
    IL-7 Signaling Pathway
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interleukin-7 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-7 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Primary immunodeficiency, organism-specific biosystem (from KEGG)
    Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • Primary immunodeficiency, conserved biosystem (from KEGG)
    Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC107557

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
homeostasis of number of cells IGI
Inferred from Genetic Interaction
more info
PubMed 
homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin production IGI
Inferred from Genetic Interaction
more info
PubMed 
lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell size IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell size IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
interleukin-7 receptor subunit alpha
Names
IL-7 receptor alpha chain
IL-7 receptor subunit alpha
IL-7R subunit alpha
IL-7R-alpha
IL-7RA
interleukin 7 receptor alpha chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355680.1NP_001342609.1  interleukin-7 receptor subunit alpha isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC162301
    Conserved Domains (1) summary
    pfam00041
    Location:131219
    fn3; Fibronectin type III domain
  2. NM_008372.4NP_032398.3  interleukin-7 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_032398.3

    Status: VALIDATED

    Source sequence(s)
    AK040364, AK042264, BC089571, BY776757
    Consensus CDS
    CCDS27376.1
    UniProtKB/Swiss-Prot
    P16872
    UniProtKB/TrEMBL
    Q5FW78, Q8C9W4
    Related
    ENSMUSP00000003981.4, ENSMUST00000003981.5
    Conserved Domains (1) summary
    pfam00041
    Location:131219
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    9506159..9529935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316439.1XP_017171928.1  interleukin-7 receptor subunit alpha isoform X1

    Related
    ENSMUSP00000154530.1, ENSMUST00000228782.1
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