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Il7r interleukin 7 receptor [ Mus musculus (house mouse) ]

Gene ID: 16197, updated on 5-Mar-2024

Summary

Official Symbol
Il7rprovided by MGI
Official Full Name
interleukin 7 receptorprovided by MGI
Primary source
MGI:MGI:96562
See related
Ensembl:ENSMUSG00000003882 AllianceGenome:MGI:96562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD127; IL-7Ralpha
Summary
Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen adult (RPKM 3.1), thymus adult (RPKM 2.6) and 8 other tissues See more
Orthologs
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Genomic context

See Il7r in Genome Data Viewer
Location:
15 A1; 15 4.16 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (9505880..9530270, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (9506159..9529941, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37938 Neighboring gene STARR-seq mESC enhancer starr_37939 Neighboring gene UDP glycosyltransferases 3 family, polypeptide A1 pseudogene Neighboring gene calcyphosine-like Neighboring gene sperm flagellar 2 Neighboring gene STARR-seq mESC enhancer starr_37942 Neighboring gene STARR-seq mESC enhancer starr_37943 Neighboring gene STARR-seq mESC enhancer starr_37944 Neighboring gene STARR-seq mESC enhancer starr_37946 Neighboring gene STARR-positive B cell enhancer ABC_E9157 Neighboring gene STARR-seq mESC enhancer starr_37947 Neighboring gene STARR-seq mESC enhancer starr_37948 Neighboring gene STARR-seq mESC enhancer starr_37949 Neighboring gene STARR-seq mESC enhancer starr_37950 Neighboring gene predicted gene, 41268 Neighboring gene prolactin receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107557

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within B cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within immunoglobulin production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell size IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell size IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-7 receptor subunit alpha
Names
IL-7 receptor alpha chain
IL-7 receptor subunit alpha
IL-7R subunit alpha
IL-7R-alpha
IL-7RA
interleukin 7 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355680.1NP_001342609.1  interleukin-7 receptor subunit alpha isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC162301
    Consensus CDS
    CCDS88732.1
    UniProtKB/TrEMBL
    A0A2I3BRC2, Q5FW78
    Related
    ENSMUSP00000154530.2, ENSMUST00000228782.2
    Conserved Domains (1) summary
    pfam00041
    Location:131219
    fn3; Fibronectin type III domain
  2. NM_008372.4NP_032398.3  interleukin-7 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_032398.3

    Status: VALIDATED

    Source sequence(s)
    AK040364, AK042264, BC089571, BY776757
    Consensus CDS
    CCDS27376.1
    UniProtKB/Swiss-Prot
    P16872, Q9R0C1
    UniProtKB/TrEMBL
    Q8C9W4
    Related
    ENSMUSP00000003981.5, ENSMUST00000003981.6
    Conserved Domains (1) summary
    pfam00041
    Location:131219
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    9505880..9530270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159168.1XP_036015061.1  interleukin-7 receptor subunit alpha isoform X1

    Conserved Domains (1) summary
    cl21522
    Location:1199
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_036159169.1XP_036015062.1  interleukin-7 receptor subunit alpha isoform X2

RNA

  1. XR_003951356.2 RNA Sequence