Il5ra interleukin 5 receptor, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il5raprovided by MGI
Official Full Name: interleukin 5 receptor, alphaprovided by MGI
Primary source: MGI:MGI:96558
See related: Ensembl:ENSMUSG00000005364 AllianceGenome:MGI:96558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il5r; CD125; CDw125
Summary: Predicted to enable cytokine binding activity and cytokine receptor activity. Acts upstream of or within cellular response to organic substance; inflammatory response to antigenic stimulus; and regulation of interleukin-5 production. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in early conceptus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5RA (interleukin 5 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 E1; 6 49.19 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_04	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (106687336..106725998, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (106710375..106749037, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

More than neutrophils: Lin(+)Ly6G(+)IL-5Ralpha(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes.
Title: More than neutrophils: Lin(+)Ly6G(+)IL-5Rα(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes.
Expression of IL-5 receptor alpha by murine and human lung neutrophils.
Title: Expression of IL-5 receptor alpha by murine and human lung neutrophils.
SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells.
Title: SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Rα-dependent mechanism in B-1 cells.
Deglycosylated variant Il5ralpha has the same ligand binding affinity and biological activity as fully glycosylated IL5Ralpha, thus demonstrating a unique role for Asn196 glycosylation in IL5Ralpha function.
Title: A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor α.
We identified B-1 progenitors expressing low levels of IL-5 receptor alpha chain (IL-5Ralpha) and eosinophil progenitors expressing higher levels of IL-5Ralpha in the fetal liver
Title: Expression of IL-5Ralpha on B-1 cell progenitors in mouse fetal liver and involvement of Bruton's tyrosine kinase in their development.
Octamer Transcription Factor 2 (Oct2) augments the ability of activated B cells to differentiate to antibody-secreting plasma cells under T cell-dependent conditions through regulation of the gene encoding the interleukin 5 receptor alpha chain.
Title: Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells.
Interleukin-5 receptor alpha chain expression and splicing during brain development in mice.
Title: Interleukin-5 receptor alpha chain expression and splicing during brain development in mice.
IL-5 is not necessary for differential splicing to occur in vivo, as all three forms of the IL-5R alpha are detected in both strains of IL-5 gene-deleted mice
Title: Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo.
The murine interleukin-5 receptor alpha chain pre-mRNA is alternatively spliced, resulting in soluble isoforms lacking the transmembrane coding region which do not complex with the IL-5R beta chain.
Title: Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Il5ra (e-PCR), detects polymorphism
- UniSTS:265226

D90205 (e-PCR)
- UniSTS:159553

Il5ra (e-PCR), detects polymorphism
- UniSTS:143573

NoName (e-PCR)
- UniSTS:491246

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables interleukin-5 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-5-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: interleukin-5 receptor subunit alpha

Names: IL-5 receptor alpha chain; IL-5 receptor subunit alpha; IL-5R subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008370.2 → NP_032396.1 interleukin-5 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_032396.1

Status: VALIDATED

Source sequence(s)

AC164169

Consensus CDS

CCDS20396.1

UniProtKB/Swiss-Prot

P21183

UniProtKB/TrEMBL

Q05A81

Related

ENSMUSP00000144718.2, ENSMUST00000204659.3

Conserved Domains (2) summary

cd00063
Location:237 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:128 → 233

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

106687336..106725998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321406.1 → XP_017176895.1 interleukin-5 receptor subunit alpha isoform X1

UniProtKB/Swiss-Prot

P21183

UniProtKB/TrEMBL

Q05A81

Conserved Domains (2) summary

cd00063
Location:237 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:128 → 233

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding