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Il4ra interleukin 4 receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 16190, updated on 26-Jun-2024

Summary

Official Symbol
Il4raprovided by MGI
Official Full Name
interleukin 4 receptor, alphaprovided by MGI
Primary source
MGI:MGI:105367
See related
Ensembl:ENSMUSG00000030748 AllianceGenome:MGI:105367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il4r; CD124
Summary
Predicted to enable cytokine receptor activity. Involved in positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; and positive regulation of macrophage activation. Acts upstream of or within several processes, including defense response to protozoan; negative regulation of T-helper 1 cell differentiation; and positive regulation of immune effector process. Predicted to be located in several cellular components, including centriolar satellite; extracellular space; and nucleoplasm. Predicted to be part of receptor complex. Is expressed in several structures, including adrenal medulla; early conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and renal tuberculosis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 39.6), adrenal adult (RPKM 36.7) and 18 other tissues See more
Orthologs
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Genomic context

See Il4ra in Genome Data Viewer
Location:
7 F3; 7 68.94 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125151443..125178646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (125552271..125579474)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132615846-132616029 Neighboring gene NSE1 homolog, SMC5-SMC6 complex component Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132635019-132635206 Neighboring gene STARR-positive B cell enhancer ABC_E3749 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132700351-132700626 Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132727524-132727725 Neighboring gene STARR-seq mESC enhancer starr_20123 Neighboring gene STARR-positive B cell enhancer ABC_E2251 Neighboring gene STARR-positive B cell enhancer ABC_E6598 Neighboring gene STARR-positive B cell enhancer ABC_E2847 Neighboring gene interleukin 21 receptor Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132773929-132774138 Neighboring gene STARR-positive B cell enhancer ABC_E11367 Neighboring gene general transcription factor III C 1 Neighboring gene STARR-positive B cell enhancer ABC_E2848

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118473

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables interleukin-4 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of T-helper 1 cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of T-helper 2 cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-4-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T-helper 1 cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in production of molecular mediator involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
interleukin-4 receptor subunit alpha
Names
IL-4 receptor alpha chain
IL-4 receptor subunit alpha
IL-4R subunit alpha
IL-4R-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008700.4NP_001008700.1  interleukin-4 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_001008700.1

    Status: VALIDATED

    Source sequence(s)
    AK159375, BC112911
    Consensus CDS
    CCDS40121.1
    UniProtKB/Swiss-Prot
    O54690, P16382, Q60583, Q8CBW5
    UniProtKB/TrEMBL
    Q3U905
    Related
    ENSMUSP00000033004.7, ENSMUST00000033004.8
    Conserved Domains (2) summary
    cd00063
    Location:124221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32122
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
  2. NM_001363983.1NP_001350912.1  interleukin-4 receptor subunit alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125213
    Conserved Domains (1) summary
    cl26464
    Location:211475
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    125151443..125178646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)