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Il2 interleukin 2 [ Mus musculus (house mouse) ]

Gene ID: 16183, updated on 14-Nov-2021

Summary

Official Symbol
Il2provided by MGI
Official Full Name
interleukin 2provided by MGI
Primary source
MGI:MGI:96548
See related
Ensembl:ENSMUSG00000027720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il-2
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Il2 in Genome Data Viewer
Location:
3 B; 3 18.3 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (37174862..37180103, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (37120713..37125954, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (37019635..37024876, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene adenosine deaminase domain containing 1 (testis specific) Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene 12584 Neighboring gene predicted gene, 36000 Neighboring gene predicted gene 12532

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosphingolipid binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-2 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables interleukin-2 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables kappa-type opioid receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to biotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of T-helper 17 cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of plasma cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T cell homeostatic proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-2
Names
T-cell growth factor
TCGF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008366.3NP_032392.1  interleukin-2 precursor

    See identical proteins and their annotated locations for NP_032392.1

    Status: VALIDATED

    Source sequence(s)
    BX519775, K02292
    Consensus CDS
    CCDS17316.1
    UniProtKB/Swiss-Prot
    P04351
    Related
    ENSMUSP00000029275.6, ENSMUST00000029275.6
    Conserved Domains (1) summary
    smart00189
    Location:1168
    IL2; Interleukin-2 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    37174862..37180103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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