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EXD1 exonuclease 3'-5' domain containing 1 [ Homo sapiens (human) ]

Gene ID: 161829, updated on 23-Nov-2021

Summary

Official Symbol
EXD1provided by HGNC
Official Full Name
exonuclease 3'-5' domain containing 1provided by HGNC
Primary source
HGNC:HGNC:28507
See related
Ensembl:ENSG00000178997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EXDL1
Expression
Restricted expression toward testis (RPKM 6.1) See more
Orthologs
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Genomic context

See EXD1 in Genome Data Viewer
Location:
15q15.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41182728..41231074, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41474926..41522955, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene INO80 complex ATPase subunit Neighboring gene CYCS pseudogene 2 Neighboring gene CIBAR1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 497, pseudogene Neighboring gene calcineurin like EF-hand protein 1 Neighboring gene OIP5 antisense RNA 1 Neighboring gene Opa interacting protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33637

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables 3'-5' exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in gene silencing by RNA ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in piRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in P granule ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of PET complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
piRNA biogenesis protein EXD1
Names
exonuclease 3'-5' domain-containing protein 1
exonuclease 3'-5' domain-like-containing protein 1
inactive exonuclease EXD1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286441.2NP_001273370.1  piRNA biogenesis protein EXD1 isoform 1

    See identical proteins and their annotated locations for NP_001273370.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC022408, AK302864, BC030628, DC404441
    Consensus CDS
    CCDS66738.1
    UniProtKB/Swiss-Prot
    Q8NHP7
    Related
    ENSP00000415056.2, ENST00000458580.7
    Conserved Domains (1) summary
    cd06148
    Location:147345
    Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
  2. NM_001385036.1NP_001371965.1  piRNA biogenesis protein EXD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012652, AC022408
    Conserved Domains (1) summary
    cd06148
    Location:124322
    Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
  3. NM_152596.4NP_689809.2  piRNA biogenesis protein EXD1 isoform 2

    See identical proteins and their annotated locations for NP_689809.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC022408, BC030628, DC404441
    Consensus CDS
    CCDS10072.1
    UniProtKB/Swiss-Prot
    Q8NHP7
    Related
    ENSP00000321029.5, ENST00000314992.9
    Conserved Domains (1) summary
    cd06148
    Location:89287
    Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    41182728..41231074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521298.2XP_011519600.1  piRNA biogenesis protein EXD1 isoform X1

    See identical proteins and their annotated locations for XP_011519600.1

    UniProtKB/Swiss-Prot
    Q8NHP7
    Conserved Domains (1) summary
    cd06148
    Location:147345
    Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
  2. XM_011521301.2XP_011519603.1  piRNA biogenesis protein EXD1 isoform X5

    Conserved Domains (1) summary
    cd06148
    Location:112310
    Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
  3. XM_011521299.2XP_011519601.1  piRNA biogenesis protein EXD1 isoform X3

    Conserved Domains (1) summary
    cd06148
    Location:93291
    Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
  4. XM_017021971.1XP_016877460.1  piRNA biogenesis protein EXD1 isoform X4

    Conserved Domains (1) summary
    cd06148
    Location:53251
    Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
  5. XM_017021970.1XP_016877459.1  piRNA biogenesis protein EXD1 isoform X4

    Conserved Domains (1) summary
    cd06148
    Location:53251
    Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
  6. XM_011521300.2XP_011519602.1  piRNA biogenesis protein EXD1 isoform X4

    Conserved Domains (1) summary
    cd06148
    Location:53251
    Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
  7. XM_011521302.2XP_011519604.1  piRNA biogenesis protein EXD1 isoform X6

    See identical proteins and their annotated locations for XP_011519604.1

    Conserved Domains (1) summary
    cl10012
    Location:1142
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
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