U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MAPDA N6-Methyl-AMP deaminase [ Homo sapiens (human) ]

Gene ID: 161823, updated on 25-Nov-2025
Official Symbol
MAPDAprovided by HGNC
Official Full Name
N6-Methyl-AMP deaminaseprovided by HGNC
Primary source
HGNC:HGNC:31853
See related
Ensembl:ENSG00000168803 MIM:619346; AllianceGenome:HGNC:31853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADAL; HsMAPDA
Summary
Predicted to enable adenosine deaminase activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to act upstream of or within response to alcohol. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in heart (RPKM 4.3), testis (RPKM 3.5) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See MAPDA in Genome Data Viewer
Location:
15q15.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43330351..43354569)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (41137658..41161894)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43622549..43646767)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 1 Neighboring gene transglutaminase 7 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:43589862-43590498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:43622679-43623629 Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43647073-43647266 Neighboring gene zinc finger and SCAN domain containing 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9313 Neighboring gene tubulin gamma complex component 4 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. ADGR: Admixture-Informed Differential Gene Regulation. Lee IH, et al. Genes (Basel), 2023 Jan 5. PMID 36672888, Free PMC Article
  2. Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. Frey CR, et al. Anticancer Res, 2013 May. PMID 23645737
  3. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. Murakami E, et al. J Med Chem, 2011 Aug 25. PMID 21755941
  4. Phylogenetic analysis reveals a novel protein family closely related to adenosine deaminase. Maier SA, et al. J Mol Evol, 2005 Dec. PMID 16245011
  5. Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism. Ogawa A, et al. Cell, 2025 Oct 30. PMID 40840445

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADGR: Admixture-Informed Differential Gene Regulation.
    Title: ADGR: Admixture-Informed Differential Gene Regulation.
  2. Mutations in adenosine deaminase-like (ADAL) protein confer drug resistance in Uterine Cervical Neoplasms.
    Title: Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.
  3. Data indicated that ADAL1 specifically acts at the 6-position of purine and 2-aminopurine nucleoside monophosphates.
    Title: Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ44620, DKFZp313B2137

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N6-methyl-AMP deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N6-methyl-AMP deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in toxic metabolite repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in toxic metabolite repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
Preferred Names
N6-Methyl-AMP deaminase
Names
N6-mAMP deaminase
N6-methyl-AMP aminohydrolase
adenosine deaminase like
adenosine deaminase-like protein
NP_001012987.1
NP_001152752.1
NP_001311293.1
NP_001311294.1
NP_001311295.1
NP_001311296.1
NP_001311297.1
XP_011519593.1
XP_016877453.1
XP_016877454.1
XP_016877455.1
XP_016877456.1
XP_016877457.1
XP_024305626.1
XP_047288158.1
XP_047288159.1
XP_047288160.1
XP_047288161.1
XP_047288162.1
XP_047288163.1
XP_047288164.1
XP_054233360.1
XP_054233361.1
XP_054233362.1
XP_054233363.1
XP_054233364.1
XP_054233365.1
XP_054233366.1
XP_054233367.1
XP_054233368.1
XP_054233369.1
XP_054233370.1
XP_054233371.1
XP_054233372.1
XP_054233373.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012969.4 → NP_001012987.1  N6-Methyl-AMP deaminase isoform 2

    See identical proteins and their annotated locations for NP_001012987.1

    Status: VALIDATED

    Source sequence(s)
    AK298870, BC075857, BQ015642, HY164938
    Consensus CDS
    CCDS32214.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Related
    ENSP00000374302.4, ENST00000389651.8
    Conserved Domains (1) summary
    cd00443
    Location:18 → 257
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  2. NM_001159280.3 → NP_001152752.1  N6-Methyl-AMP deaminase isoform 1

    See identical proteins and their annotated locations for NP_001152752.1

    Status: VALIDATED

    Source sequence(s)
    AC018924, AK298870, BC075857, HY164938
    Consensus CDS
    CCDS53936.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Related
    ENSP00000413074.3, ENST00000428046.7
    Conserved Domains (1) summary
    cd00443
    Location:18 → 318
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  3. NM_001324364.2 → NP_001311293.1  N6-Methyl-AMP deaminase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Consensus CDS
    CCDS32214.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Conserved Domains (1) summary
    cd00443
    Location:18 → 257
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  4. NM_001324365.2 → NP_001311294.1  N6-Methyl-AMP deaminase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Consensus CDS
    CCDS32214.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Conserved Domains (1) summary
    cd00443
    Location:18 → 257
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  5. NM_001324366.2 → NP_001311295.1  N6-Methyl-AMP deaminase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Consensus CDS
    CCDS81868.1
    UniProtKB/Swiss-Prot
    A6NHZ3, B4DQM8, Q6DHV7
    Related
    ENSP00000456242.1, ENST00000562188.7
    Conserved Domains (1) summary
    cd00443
    Location:18 → 345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  6. NM_001324367.2 → NP_001311296.1  N6-Methyl-AMP deaminase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Conserved Domains (1) summary
    cl00281
    Location:18 → 230
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  7. NM_001324368.2 → NP_001311297.1  N6-Methyl-AMP deaminase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Consensus CDS
    CCDS32214.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Conserved Domains (1) summary
    cd00443
    Location:18 → 257
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    43330351..43354569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021965.2 → XP_016877454.1  N6-Methyl-AMP deaminase isoform X1

    UniProtKB/Swiss-Prot
    A6NHZ3, B4DQM8, Q6DHV7
    Related
    ENSP00000622096.1, ENST00000952037.1
    Conserved Domains (1) summary
    cd00443
    Location:18 → 345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  2. XM_047432207.1 → XP_047288163.1  N6-Methyl-AMP deaminase isoform X4

  3. XM_047432203.1 → XP_047288159.1  N6-Methyl-AMP deaminase isoform X2

  4. XM_017021968.2 → XP_016877457.1  N6-Methyl-AMP deaminase isoform X4

    Conserved Domains (1) summary
    cl00281
    Location:18 → 257
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  5. XM_047432208.1 → XP_047288164.1  N6-Methyl-AMP deaminase isoform X5

  6. XM_011521291.3 → XP_011519593.1  N6-Methyl-AMP deaminase isoform X1

    See identical proteins and their annotated locations for XP_011519593.1

    UniProtKB/Swiss-Prot
    A6NHZ3, B4DQM8, Q6DHV7
    Related
    ENSP00000578806.1, ENST00000908747.1
    Conserved Domains (1) summary
    cd00443
    Location:18 → 345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  7. XM_047432205.1 → XP_047288161.1  N6-Methyl-AMP deaminase isoform X4

  8. XM_024449858.2 → XP_024305626.1  N6-Methyl-AMP deaminase isoform X2

    Related
    ENSP00000398744.3, ENST00000422466.6
    Conserved Domains (1) summary
    cd00443
    Location:18 → 318
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  9. XM_017021967.2 → XP_016877456.1  N6-Methyl-AMP deaminase isoform X3

  10. XM_017021966.3 → XP_016877455.1  N6-Methyl-AMP deaminase isoform X1

    UniProtKB/Swiss-Prot
    A6NHZ3, B4DQM8, Q6DHV7
    Related
    ENSP00000600953.1, ENST00000930894.1
    Conserved Domains (1) summary
    cd00443
    Location:18 → 345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  11. XM_047432204.1 → XP_047288160.1  N6-Methyl-AMP deaminase isoform X2

  12. XM_017021964.3 → XP_016877453.1  N6-Methyl-AMP deaminase isoform X1

    UniProtKB/Swiss-Prot
    A6NHZ3, B4DQM8, Q6DHV7
    Related
    ENSP00000578804.1, ENST00000908745.1
    Conserved Domains (1) summary
    cd00443
    Location:18 → 345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  13. XM_047432206.1 → XP_047288162.1  N6-Methyl-AMP deaminase isoform X4

  14. XM_047432202.1 → XP_047288158.1  N6-Methyl-AMP deaminase isoform X2

    Related
    ENSP00000578805.1, ENST00000908746.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    41137658..41161894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377387.1 → XP_054233362.1  N6-Methyl-AMP deaminase isoform X1

    UniProtKB/Swiss-Prot
    A6NHZ3, B4DQM8, Q6DHV7

  2. XM_054377397.1 → XP_054233372.1  N6-Methyl-AMP deaminase isoform X4

  3. XM_054377391.1 → XP_054233366.1  N6-Methyl-AMP deaminase isoform X2

  4. XM_054377394.1 → XP_054233369.1  N6-Methyl-AMP deaminase isoform X4

  5. XM_054377398.1 → XP_054233373.1  N6-Methyl-AMP deaminase isoform X5

  6. XM_054377385.1 → XP_054233360.1  N6-Methyl-AMP deaminase isoform X1

    UniProtKB/Swiss-Prot
    A6NHZ3, B4DQM8, Q6DHV7

  7. XM_054377395.1 → XP_054233370.1  N6-Methyl-AMP deaminase isoform X4

  8. XM_054377389.1 → XP_054233364.1  N6-Methyl-AMP deaminase isoform X2

  9. XM_054377393.1 → XP_054233368.1  N6-Methyl-AMP deaminase isoform X3

  10. XM_054377388.1 → XP_054233363.1  N6-Methyl-AMP deaminase isoform X1

    UniProtKB/Swiss-Prot
    A6NHZ3, B4DQM8, Q6DHV7

  11. XM_054377392.1 → XP_054233367.1  N6-Methyl-AMP deaminase isoform X2

  12. XM_054377386.1 → XP_054233361.1  N6-Methyl-AMP deaminase isoform X1

    UniProtKB/Swiss-Prot
    A6NHZ3, B4DQM8, Q6DHV7

  13. XM_054377396.1 → XP_054233371.1  N6-Methyl-AMP deaminase isoform X4

  14. XM_054377390.1 → XP_054233365.1  N6-Methyl-AMP deaminase isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DHV7.2 GenPept UniProtKB/Swiss-Prot:Q6DHV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous