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ADAL adenosine deaminase like [ Homo sapiens (human) ]

Gene ID: 161823, updated on 5-Sep-2021

Summary

Official Symbol
ADALprovided by HGNC
Official Full Name
adenosine deaminase likeprovided by HGNC
Primary source
HGNC:HGNC:31853
See related
Ensembl:ENSG00000168803 MIM:619346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsMAPDA
Expression
Broad expression in heart (RPKM 4.3), testis (RPKM 3.5) and 24 other tissues See more
Orthologs
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Genomic context

See ADAL in Genome Data Viewer
Location:
15q15.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43330341..43354569)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43622549..43646767)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 1 Neighboring gene transglutaminase 7 Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene zinc finger and SCAN domain containing 29 Neighboring gene tubulin gamma complex associated protein 4 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44620, DKFZp313B2137

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N6-mAMP deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adenosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adenosine deaminase-like protein
Names
N6-mAMP deaminase
N6-methyl-AMP aminohydrolase
NP_001012987.1
NP_001152752.1
NP_001311293.1
NP_001311294.1
NP_001311295.1
NP_001311296.1
NP_001311297.1
XP_011519593.1
XP_016877453.1
XP_016877454.1
XP_016877455.1
XP_016877456.1
XP_016877457.1
XP_016877458.1
XP_024305626.1
XP_024305627.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012969.4NP_001012987.1  adenosine deaminase-like protein isoform 2

    See identical proteins and their annotated locations for NP_001012987.1

    Status: VALIDATED

    Source sequence(s)
    AK298870, BC075857, BQ015642, HY164938
    Consensus CDS
    CCDS32214.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Related
    ENSP00000374302.4, ENST00000389651.8
    Conserved Domains (1) summary
    cd00443
    Location:18257
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  2. NM_001159280.3NP_001152752.1  adenosine deaminase-like protein isoform 1

    See identical proteins and their annotated locations for NP_001152752.1

    Status: VALIDATED

    Source sequence(s)
    AC018924, AK298870, BC075857, HY164938
    Consensus CDS
    CCDS53936.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Related
    ENSP00000413074.3, ENST00000428046.7
    Conserved Domains (1) summary
    cd00443
    Location:18318
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  3. NM_001324364.2NP_001311293.1  adenosine deaminase-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Consensus CDS
    CCDS32214.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Conserved Domains (1) summary
    cd00443
    Location:18257
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  4. NM_001324365.2NP_001311294.1  adenosine deaminase-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Consensus CDS
    CCDS32214.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Conserved Domains (1) summary
    cd00443
    Location:18257
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  5. NM_001324366.2NP_001311295.1  adenosine deaminase-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Consensus CDS
    CCDS81868.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    UniProtKB/TrEMBL
    A0A024R9S2
    Related
    ENSP00000456242.1, ENST00000562188.7
    Conserved Domains (1) summary
    cd00443
    Location:18345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  6. NM_001324367.2NP_001311296.1  adenosine deaminase-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Conserved Domains (1) summary
    cl00281
    Location:18230
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  7. NM_001324368.2NP_001311297.1  adenosine deaminase-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009852, AC018924
    Consensus CDS
    CCDS32214.1
    UniProtKB/Swiss-Prot
    Q6DHV7
    Conserved Domains (1) summary
    cd00443
    Location:18257
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43330341..43354569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449859.1XP_024305627.1  adenosine deaminase-like protein isoform X5

    Conserved Domains (1) summary
    cl00281
    Location:29222
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  2. XM_017021965.1XP_016877454.1  adenosine deaminase-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q6DHV7
    UniProtKB/TrEMBL
    A0A024R9S2
    Conserved Domains (1) summary
    cd00443
    Location:18345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  3. XM_017021964.2XP_016877453.1  adenosine deaminase-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q6DHV7
    UniProtKB/TrEMBL
    A0A024R9S2
    Conserved Domains (1) summary
    cd00443
    Location:18345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  4. XM_017021968.1XP_016877457.1  adenosine deaminase-like protein isoform X4

    Conserved Domains (1) summary
    cl00281
    Location:18257
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  5. XM_017021966.2XP_016877455.1  adenosine deaminase-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q6DHV7
    UniProtKB/TrEMBL
    A0A024R9S2
    Conserved Domains (1) summary
    cd00443
    Location:18345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  6. XM_011521291.2XP_011519593.1  adenosine deaminase-like protein isoform X1

    See identical proteins and their annotated locations for XP_011519593.1

    UniProtKB/Swiss-Prot
    Q6DHV7
    UniProtKB/TrEMBL
    A0A024R9S2
    Conserved Domains (1) summary
    cd00443
    Location:18345
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  7. XM_024449858.1XP_024305626.1  adenosine deaminase-like protein isoform X2

    Conserved Domains (1) summary
    cd00443
    Location:18318
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
  8. XM_017021969.1XP_016877458.1  adenosine deaminase-like protein isoform X6

    Conserved Domains (1) summary
    cl00281
    Location:18230
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  9. XM_017021967.1XP_016877456.1  adenosine deaminase-like protein isoform X3

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