Il1rn interleukin 1 receptor antagonist [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il1rnprovided by MGI
Official Full Name: interleukin 1 receptor antagonistprovided by MGI
Primary source: MGI:MGI:96547
See related: Ensembl:ENSMUSG00000026981 AllianceGenome:MGI:96547
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-1ra; F630041P17Rik
Summary: Predicted to enable cytokine receptor binding activity. Acts upstream of or within insulin secretion and lipid metabolic process. Located in extracellular region and vesicle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E18 (RPKM 5.5), colon adult (RPKM 5.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 16.36 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (24226872..24241503)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (24336860..24351491)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia inducible factor 1alpha promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury.
Title: Hypoxia inducible factor 1α promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury.
Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis.
Title: Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis.
Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines.
Title: Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines.
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
Title: IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
Impact of thermogenesis induced by chronic beta3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
Title: Impact of thermogenesis induced by chronic β3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
Bone Marrow-Derived IL-1Ra Increases TNF Levels Poststroke.
Title: Bone Marrow-Derived IL-1Ra Increases TNF Levels Poststroke.
Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3.
Title: Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3.
IL1RN promotes osteoblastic differentiation via interacting with ITGB3 in osteoporosis.
Title: IL1RN promotes osteoblastic differentiation via interacting with ITGB3 in osteoporosis.
Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice.
Title: Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice.
Increase in the Number of Bone Marrow Osteoclast Precursors at Different Skeletal Sites, Particularly in Long Bone and Jaw Marrow in Mice Lacking IL-1RA.
Title: Increase in the Number of Bone Marrow Osteoclast Precursors at Different Skeletal Sites, Particularly in Long Bone and Jaw Marrow in Mice Lacking IL-1RA.

Submit: New GeneRIF Correction See all GeneRIFs (84)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224661

Il1rn (e-PCR), detects polymorphism
- UniSTS:143547

Il1rn (e-PCR), detects polymorphism
- UniSTS:143548

Il1rn (e-PCR), detects polymorphism
- UniSTS:143549

M64404 (e-PCR)
- UniSTS:158925

Homology

Homologs of the Il1rn gene: The Il1rn gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 174 organisms have orthologs with human gene Il1rn
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables interleukin-1 receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1 receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 type I receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1 type II receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1, type I receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1, type II receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	ISO Inferred from Sequence Orthology more info
involved_in fever generation	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to antigenic stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-1 receptor antagonist protein

Names: IL-1RN; IL1 inhibitor; IRAP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039701.3 → NP_001034790.1 interleukin-1 receptor antagonist protein isoform 2 precursor

See identical proteins and their annotated locations for NP_001034790.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate segment compared to variant 3, that removes the translation initiation site. The resulting isoform (2) starts at a downstream AUG and has a shorter and distinct N-terminus compared to isoform 3.

Source sequence(s)

AK155641, AL732528

Consensus CDS

CCDS38064.1

UniProtKB/Swiss-Prot

O70207, P25085

UniProtKB/TrEMBL

Q542C7

Related

ENSMUSP00000110126.2, ENSMUST00000114482.3

Conserved Domains (1) summary

smart00125
Location:34 → 175

IL1; Interleukin-1 homologues
NM_001159562.1 → NP_001153034.1 interleukin-1 receptor antagonist protein isoform 3

See identical proteins and their annotated locations for NP_001153034.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AL732528, BY206809

Consensus CDS

CCDS50520.1

UniProtKB/TrEMBL

A0A8C6I2Y4, Q3TBV5

Related

ENSMUSP00000110129.3, ENSMUST00000114485.9

Conserved Domains (1) summary

smart00125
Location:18 → 159

IL1; Interleukin-1 homologues
NM_031167.5 → NP_112444.1 interleukin-1 receptor antagonist protein isoform 1

See identical proteins and their annotated locations for NP_112444.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.

Source sequence(s)

AK076296, AL732528

Consensus CDS

CCDS15736.1

UniProtKB/Swiss-Prot

P25085

UniProtKB/TrEMBL

A0A8C6I494, Q542W1

Related

ENSMUSP00000110131.3, ENSMUST00000114487.9

Conserved Domains (1) summary

smart00125
Location:15 → 156

IL1; Interleukin-1 homologues

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

24226872..24241503

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497727.4 → XP_006497790.1 interleukin-1 receptor antagonist protein isoform X1

Conserved Domains (1) summary

smart00125
Location:1 → 140

IL1; Interleukin-1 homologues