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Il1rn interleukin 1 receptor antagonist [ Mus musculus (house mouse) ]

Gene ID: 16181, updated on 5-Jan-2023

Summary

Official Symbol
Il1rnprovided by MGI
Official Full Name
interleukin 1 receptor antagonistprovided by MGI
Primary source
MGI:MGI:96547
See related
Ensembl:ENSMUSG00000026981 AllianceGenome:MGI:96547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL-1ra; F630041P17Rik
Summary
Predicted to enable cytokine receptor binding activity. Acts upstream of or within insulin secretion and lipid metabolic process. Located in extracellular region and vesicle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 5.5), colon adult (RPKM 5.1) and 18 other tissues See more
Orthologs
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Genomic context

See Il1rn in Genome Data Viewer
Location:
2 A3; 2 16.36 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24226872..24241503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24336860..24351491)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene interleukin 36 receptor antagonist Neighboring gene interleukin 1 family, member 10 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene paired box 8 Neighboring gene predicted gene 13415

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-1 receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-1 receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-1 type I receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-1 type II receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-1, type I receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-1, type II receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in acute-phase response ISO
Inferred from Sequence Orthology
more info
 
involved_in fever generation ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response to antigenic stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interleukin-1 receptor antagonist protein
Names
IL-1RN
IL1 inhibitor
IRAP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039701.3NP_001034790.1  interleukin-1 receptor antagonist protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001034790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment compared to variant 3, that removes the translation initiation site. The resulting isoform (2) starts at a downstream AUG and has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AK155641, AL732528
    Consensus CDS
    CCDS38064.1
    UniProtKB/Swiss-Prot
    O70207, P25085
    UniProtKB/TrEMBL
    Q542C7
    Related
    ENSMUSP00000110126.2, ENSMUST00000114482.3
    Conserved Domains (1) summary
    smart00125
    Location:34175
    IL1; Interleukin-1 homologues
  2. NM_001159562.1NP_001153034.1  interleukin-1 receptor antagonist protein isoform 3

    See identical proteins and their annotated locations for NP_001153034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AL732528, BY206809
    Consensus CDS
    CCDS50520.1
    UniProtKB/TrEMBL
    A0A8C6I2Y4, Q3TBV5
    Related
    ENSMUSP00000110129.3, ENSMUST00000114485.9
    Conserved Domains (1) summary
    smart00125
    Location:18159
    IL1; Interleukin-1 homologues
  3. NM_031167.5NP_112444.1  interleukin-1 receptor antagonist protein isoform 1

    See identical proteins and their annotated locations for NP_112444.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AK076296, AL732528
    Consensus CDS
    CCDS15736.1
    UniProtKB/Swiss-Prot
    P25085
    UniProtKB/TrEMBL
    A0A8C6I494, Q542W1
    Related
    ENSMUSP00000110131.3, ENSMUST00000114487.9
    Conserved Domains (1) summary
    smart00125
    Location:15156
    IL1; Interleukin-1 homologues

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24226872..24241503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497727.4XP_006497790.1  interleukin-1 receptor antagonist protein isoform X1

    Conserved Domains (1) summary
    smart00125
    Location:1140
    IL1; Interleukin-1 homologues