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Il1rn interleukin 1 receptor antagonist [ Mus musculus (house mouse) ]

Gene ID: 16181, updated on 7-Apr-2025

Summary

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Official Symbol
Il1rnprovided by MGI
Official Full Name
interleukin 1 receptor antagonistprovided by MGI
Primary source
MGI:MGI:96547
See related
Ensembl:ENSMUSG00000026981 AllianceGenome:MGI:96547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL-1ra; F630041P17Rik
Summary
Predicted to enable cytokine receptor binding activity. Acts upstream of or within insulin secretion and lipid metabolic process. Located in extracellular region and vesicle. Is expressed in skin. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in liver E18 (RPKM 5.5), colon adult (RPKM 5.1) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Il1rn in Genome Data Viewer
Location:
2 A3; 2 16.36 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24226872..24241503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24336860..24351491)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene interleukin 36 receptor antagonist Neighboring gene STARR-positive B cell enhancer ABC_E7798 Neighboring gene interleukin 1 family, member 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24238515-24238668 Neighboring gene STARR-positive B cell enhancer ABC_E11125 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene paired box 8 Neighboring gene predicted gene 13415

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging. Wakabayashi C, et al. Neurosci Lett, 2015 Jul 10. PMID 26002078
  2. Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia. Pinteaux E, et al. Glia, 2006 Apr 1. PMID 16374779
  3. Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents. Somm E, et al. Diabetologia, 2006 Feb. PMID 16385385
  4. Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist. Lee K, et al. PLoS One, 2018. PMID 29481574, Free PMC Article
  5. Airway Remodeling and Hyperreactivity in a Model of Bronchopulmonary Dysplasia and Their Modulation by IL-1 Receptor Antagonist. Royce SG, et al. Am J Respir Cell Mol Biol, 2016 Dec. PMID 27482635

See all (203) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosome microRNA-125a-5p derived from epithelium promotes M1 macrophage polarization by targeting IL1RN in chronic obstructive pulmonary disease.
    Title: Exosome microRNA-125a-5p derived from epithelium promotes M1 macrophage polarization by targeting IL1RN in chronic obstructive pulmonary disease.
  2. Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection.
    Title: Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection.
  3. The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
    Title: The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
  4. Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion.
    Title: Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion.
  5. Hypoxia inducible factor 1alpha promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury.
    Title: Hypoxia inducible factor 1α promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury.
  6. Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis.
    Title: Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis.
  7. Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines.
    Title: Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines.
  8. IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
    Title: IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
  9. Impact of thermogenesis induced by chronic beta3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
    Title: Impact of thermogenesis induced by chronic β3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
  10. Bone Marrow-Derived IL-1Ra Increases TNF Levels Poststroke.
    Title: Bone Marrow-Derived IL-1Ra Increases TNF Levels Poststroke.
Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1 type I receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 type I receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1 type II receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 type II receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1, type I receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1, type I receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1, type II receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1, type II receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acute-phase response ISO
Inferred from Sequence Orthology
more info
  
involved_in fever generation ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in memory ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interleukin-1 receptor antagonist protein
Names
IL-1RN
IL1 inhibitor
IRAP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039701.3 → NP_001034790.1  interleukin-1 receptor antagonist protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001034790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment compared to variant 3, that removes the translation initiation site. The resulting isoform (2) starts at a downstream AUG and has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AK155641, AL732528
    Consensus CDS
    CCDS38064.1
    UniProtKB/Swiss-Prot
    O70207, P25085
    UniProtKB/TrEMBL
    Q542C7, Q8CGA1
    Related
    ENSMUSP00000110126.2, ENSMUST00000114482.3
    Conserved Domains (1) summary
    smart00125
    Location:34 → 175
    IL1; Interleukin-1 homologues

  2. NM_001159562.1 → NP_001153034.1  interleukin-1 receptor antagonist protein isoform 3

    See identical proteins and their annotated locations for NP_001153034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AL732528, BY206809
    Consensus CDS
    CCDS50520.1
    UniProtKB/TrEMBL
    Q3TBV5, Q8CGA1
    Related
    ENSMUSP00000110129.3, ENSMUST00000114485.9
    Conserved Domains (1) summary
    smart00125
    Location:18 → 159
    IL1; Interleukin-1 homologues

  3. NM_031167.5 → NP_112444.1  interleukin-1 receptor antagonist protein isoform 1

    See identical proteins and their annotated locations for NP_112444.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AK076296, AL732528
    Consensus CDS
    CCDS15736.1
    UniProtKB/TrEMBL
    Q542W1, Q8CGA1
    Related
    ENSMUSP00000110131.3, ENSMUST00000114487.9
    Conserved Domains (1) summary
    smart00125
    Location:15 → 156
    IL1; Interleukin-1 homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24226872..24241503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497727.4 → XP_006497790.1  interleukin-1 receptor antagonist protein isoform X1

    UniProtKB/TrEMBL
    Q8CGA1
    Conserved Domains (1) summary
    smart00125
    Location:1 → 140
    IL1; Interleukin-1 homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25085.1 GenPept UniProtKB/Swiss-Prot:P25085

Gene LinkOut

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