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Il1a interleukin 1 alpha [ Mus musculus (house mouse) ]

Gene ID: 16175, updated on 16-Feb-2021

Summary

Official Symbol
Il1aprovided by MGI
Official Full Name
interleukin 1 alphaprovided by MGI
Primary source
MGI:MGI:96542
See related
Ensembl:ENSMUSG00000027399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il; Il-1a
Expression
Broad expression in liver E18 (RPKM 1.2), liver E14 (RPKM 1.1) and 20 other tissues See more
Orthologs
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Genomic context

See Il1a in Genome Data Viewer
Location:
2 F1; 2 62.9 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129141530..129151892, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129299609..129310186, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (129125346..129135708, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730036I17 gene Neighboring gene cytoskeleton associated protein 2-like Neighboring gene predicted gene 14023 Neighboring gene predicted gene, 29941 Neighboring gene predicted gene, 25703 Neighboring gene Casitas B-lineage lymphoma pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
copper ion binding ISO
Inferred from Sequence Orthology
more info
 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-1 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular sodium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
connective tissue replacement involved in inflammatory response wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ectopic germ cell programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
fever generation IEA
Inferred from Electronic Annotation
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
keratinization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of establishment of Sertoli cell barrier ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of immature T cell proliferation in thymus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neutrophil extravasation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neutrophil migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of nitric-oxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
response to copper ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-1 alpha
Names
IL-1 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010554.4NP_034684.2  interleukin-1 alpha

    See identical proteins and their annotated locations for NP_034684.2

    Status: VALIDATED

    Source sequence(s)
    AL772347
    Consensus CDS
    CCDS16725.1
    UniProtKB/Swiss-Prot
    P01582
    UniProtKB/TrEMBL
    Q3U0Y6
    Related
    ENSMUSP00000028882.1, ENSMUST00000028882.1
    Conserved Domains (2) summary
    smart00125
    Location:131270
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1109
    IL1_propep; Interleukin-1 propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    129141530..129151892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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