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Il18 interleukin 18 [ Mus musculus (house mouse) ]

Gene ID: 16173, updated on 8-Feb-2024

Summary

Official Symbol
Il18provided by MGI
Official Full Name
interleukin 18provided by MGI
Primary source
MGI:MGI:107936
See related
Ensembl:ENSMUSG00000039217 AllianceGenome:MGI:107936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Igif; Il-18
Summary
Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 9.4), cortex adult (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See Il18 in Genome Data Viewer
Location:
9 A5.3; 9 27.75 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50466000..50493141)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50554700..50581841)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene placenta expressed transcript 1, opposite strand Neighboring gene placenta expressed transcript 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:50341457-50341566 Neighboring gene 6-pyruvoyl-tetrahydropterin synthase Neighboring gene beta-carotene oxygenase 2 Neighboring gene testis expressed 12 Neighboring gene succinate dehydrogenase complex, subunit D, integral membrane protein Neighboring gene translocase of inner mitochondrial membrane 8B Neighboring gene NKAP domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-18 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T-helper 1 cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T-helper 1 cell cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in T-helper 1 type immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to peptide hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within immune response TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within interleukin-18-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-18-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-18-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within natural killer cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 1 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 2 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-13 production TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of male germ cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in sleep ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-18
Names
IFN-gamma-inducing factor
IL-1 gamma
interferon gamma-inducing factor
interleukin-1 gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357221.1NP_001344150.1  interleukin-18 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC025500, AC127254
    Consensus CDS
    CCDS40622.1
    UniProtKB/Swiss-Prot
    P70380
    UniProtKB/TrEMBL
    Q2PMY2, Q6USQ6
    Related
    ENSMUSP00000151002.2, ENSMUST00000214117.2
    Conserved Domains (1) summary
    cl00094
    Location:76182
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. NM_001357222.1NP_001344151.1  interleukin-18 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC025500, AC127254, AV328761
    Consensus CDS
    CCDS90562.1
    UniProtKB/TrEMBL
    A0A1L1STF5
    Related
    ENSMUSP00000150305.2, ENSMUST00000213916.2
  3. NM_008360.2NP_032386.1  interleukin-18 isoform a

    See identical proteins and their annotated locations for NP_032386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC025500, AC127254, CX123286
    Consensus CDS
    CCDS40622.1
    UniProtKB/Swiss-Prot
    P70380
    UniProtKB/TrEMBL
    Q2PMY2, Q6USQ6
    Conserved Domains (1) summary
    cl00094
    Location:76182
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50466000..50493141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510024.1XP_006510087.1  interleukin-18 isoform X2

    UniProtKB/TrEMBL
    Q6USQ6
    Conserved Domains (1) summary
    cl00094
    Location:96202
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. XM_036154618.1XP_036010511.1  interleukin-18 isoform X4

    UniProtKB/TrEMBL
    Q80SS8
    Conserved Domains (1) summary
    cl00094
    Location:60166
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  3. XM_036154619.1XP_036010512.1  interleukin-18 isoform X4

    UniProtKB/TrEMBL
    Q80SS8
    Conserved Domains (1) summary
    cl00094
    Location:60166
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  4. XM_036154616.1XP_036010509.1  interleukin-18 isoform X2

    UniProtKB/TrEMBL
    Q6USQ6
    Conserved Domains (1) summary
    cl00094
    Location:96202
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  5. XM_030244066.2XP_030099926.1  interleukin-18 isoform X2

    UniProtKB/TrEMBL
    Q6USQ6
    Conserved Domains (1) summary
    cl00094
    Location:96202
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  6. XM_036154615.1XP_036010508.1  interleukin-18 isoform X1

    Conserved Domains (1) summary
    cl00094
    Location:157263
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  7. XM_017313137.3XP_017168626.1  interleukin-18 isoform X1

    Conserved Domains (1) summary
    cl00094
    Location:157263
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  8. XM_036154617.1XP_036010510.1  interleukin-18 isoform X3

    UniProtKB/Swiss-Prot
    P70380
    UniProtKB/TrEMBL
    Q2PMY2, Q6USQ6
    Conserved Domains (1) summary
    cl00094
    Location:76182
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).