U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Il15 interleukin 15 [ Mus musculus (house mouse) ]

Gene ID: 16168, updated on 8-Jul-2024

Summary

Official Symbol
Il15provided by MGI
Official Full Name
interleukin 15provided by MGI
Primary source
MGI:MGI:103014
See related
Ensembl:ENSMUSG00000031712 AllianceGenome:MGI:103014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL-15
Summary
This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]
Expression
Broad expression in heart adult (RPKM 5.2), duodenum adult (RPKM 3.3) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Il15 in Genome Data Viewer
Location:
8 C2; 8 39.33 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (83058253..83129883, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (82331624..82403252, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9520 Neighboring gene predicted gene, 38590 Neighboring gene predicted gene, 51610 Neighboring gene STARR-seq mESC enhancer starr_22064 Neighboring gene STARR-positive B cell enhancer ABC_E2268 Neighboring gene STARR-positive B cell enhancer ABC_E9734 Neighboring gene STARR-positive B cell enhancer ABC_E11389 Neighboring gene predicted gene, 25138 Neighboring gene STARR-seq mESC enhancer starr_22065 Neighboring gene STARR-seq mESC enhancer starr_22066 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within NK T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extrathymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyaluronan metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-15-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of natural killer cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of natural killer cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of natural killer cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001254747.2NP_001241676.1  interleukin-15 preproprotein

    See identical proteins and their annotated locations for NP_001241676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC156993
    Consensus CDS
    CCDS40401.1
    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Related
    ENSMUSP00000147848.2, ENSMUST00000209363.2
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  2. NM_008357.3NP_032383.1  interleukin-15 preproprotein

    See identical proteins and their annotated locations for NP_032383.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC156993
    Consensus CDS
    CCDS40401.1
    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Related
    ENSMUSP00000034148.7, ENSMUST00000034148.7
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    83058253..83129883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530714.5XP_006530777.1  interleukin-15 isoform X2

    See identical proteins and their annotated locations for XP_006530777.1

    UniProtKB/TrEMBL
    Q1AHQ7
    Conserved Domains (1) summary
    pfam02372
    Location:33139
    IL15; Interleukin 15
  2. XM_006530715.5XP_006530778.1  interleukin-15 isoform X3

    See identical proteins and their annotated locations for XP_006530778.1

    UniProtKB/TrEMBL
    Q1AHQ6
    Conserved Domains (1) summary
    pfam02372
    Location:33138
    IL15; Interleukin 15
  3. XM_006530713.5XP_006530776.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_006530776.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  4. XM_006530708.5XP_006530771.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_006530771.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  5. XM_006530707.5XP_006530770.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_006530770.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  6. XM_006530706.5XP_006530769.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_006530769.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  7. XM_011248313.4XP_011246615.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_011246615.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  8. XM_006530712.5XP_006530775.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_006530775.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  9. XM_006530705.5XP_006530768.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_006530768.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  10. XM_036153765.1XP_036009658.1  interleukin-15 isoform X1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  11. XM_006530711.5XP_006530774.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_006530774.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  12. XM_011248312.4XP_011246614.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_011246614.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  13. XM_011248314.4XP_011246616.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_011246616.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  14. XM_030243304.2XP_030099164.1  interleukin-15 isoform X3

    UniProtKB/TrEMBL
    Q1AHQ6
    Conserved Domains (1) summary
    pfam02372
    Location:33138
    IL15; Interleukin 15
  15. XM_006530709.4XP_006530772.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_006530772.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Related
    ENSMUSP00000148256.3, ENSMUST00000209573.3
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15
  16. XM_006530710.3XP_006530773.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_006530773.1

    UniProtKB/Swiss-Prot
    P48346
    UniProtKB/TrEMBL
    Q3U1Z6
    Conserved Domains (1) summary
    pfam02372
    Location:33154
    IL15; Interleukin 15