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Il12rb2 interleukin 12 receptor, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 16162, updated on 1-Mar-2024

Summary

Official Symbol
Il12rb2provided by MGI
Official Full Name
interleukin 12 receptor, beta 2provided by MGI
Primary source
MGI:MGI:1270861
See related
Ensembl:ENSMUSG00000018341 AllianceGenome:MGI:1270861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifnm; IL-12RB2; A930027I18Rik
Summary
Enables protein kinase binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation; response to cytokine; and response to lipopolysaccharide. Located in external side of plasma membrane. Is expressed in several structures, including brain ventricular layer; genitourinary system; incisor; olfactory epithelium; and submandibular gland. Orthologous to human IL12RB2 (interleukin 12 receptor subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 1.8), cerebellum adult (RPKM 1.2) and 22 other tissues See more
Orthologs
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Genomic context

See Il12rb2 in Genome Data Viewer
Location:
6 C1; 6 30.81 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67263914..67353277, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67285986..67376293, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16173 Neighboring gene predicted gene, 38825 Neighboring gene STARR-seq mESC enhancer starr_16175 Neighboring gene Sod1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16176 Neighboring gene STARR-seq mESC enhancer starr_16180 Neighboring gene STARR-positive B cell enhancer ABC_E2787 Neighboring gene STARR-seq mESC enhancer starr_16184 Neighboring gene serpine1 mRNA binding protein 1 Neighboring gene predicted gene, 57761 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase pseudogene Neighboring gene ribosomal protein S7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
interleukin-12 receptor subunit beta-2
Names
IL-12 receptor subunit beta-2
IL-12R subunit beta-2
interferon response to microorganisms

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311141.1NP_001298070.1  interleukin-12 receptor subunit beta-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore, differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC130822, BC137745
    Consensus CDS
    CCDS80543.1
    UniProtKB/TrEMBL
    D3Z6H5
    Related
    ENSMUSP00000113267.2, ENSMUST00000117441.8
    Conserved Domains (2) summary
    cd00063
    Location:104191
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:202289
    fn3; Fibronectin type III domain
  2. NM_008354.4NP_032380.1  interleukin-12 receptor subunit beta-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC130822
    Consensus CDS
    CCDS20220.1
    UniProtKB/Swiss-Prot
    B9EHD9, P97378
    Related
    ENSMUSP00000010605.4, ENSMUST00000018485.4
    Conserved Domains (3) summary
    cd00063
    Location:240332
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:438523
    fn3; Fibronectin type III domain
    pfam06328
    Location:28120
    Lep_receptor_Ig; Ig-like C2-type domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    67263914..67353277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505617.5XP_006505680.1  interleukin-12 receptor subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006505680.1

    UniProtKB/Swiss-Prot
    B9EHD9, P97378
    Conserved Domains (3) summary
    cd00063
    Location:240332
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:438523
    fn3; Fibronectin type III domain
    pfam06328
    Location:28120
    Lep_receptor_Ig; Ig-like C2-type domain