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Il12b interleukin 12b [ Mus musculus (house mouse) ]

Gene ID: 16160, updated on 14-May-2024

Summary

Official Symbol
Il12bprovided by MGI
Official Full Name
interleukin 12bprovided by MGI
Primary source
MGI:MGI:96540
See related
Ensembl:ENSMUSG00000004296 AllianceGenome:MGI:96540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p40; Il-12b; Il12p40; Il-12p40
Summary
This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014]
Expression
Biased expression in thymus adult (RPKM 1.0), spleen adult (RPKM 0.3) and 4 other tissues See more
Orthologs
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Genomic context

See Il12b in Genome Data Viewer
Location:
11 B1.1; 11 25.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (44290890..44305504)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (44400063..44414677)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene adrenergic receptor, alpha 1b Neighboring gene STARR-seq mESC enhancer starr_29271 Neighboring gene predicted gene 12153 Neighboring gene STARR-seq mESC enhancer starr_29272 Neighboring gene STARR-seq mESC enhancer starr_29274 Neighboring gene STARR-seq mESC enhancer starr_29278 Neighboring gene STARR-seq mESC enhancer starr_29279 Neighboring gene STARR-positive B cell enhancer ABC_E5216 Neighboring gene STARR-positive B cell enhancer mm9_chr11:44292046-44292346 Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 Neighboring gene adenosine kinase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to cytokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-12 alpha subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables interleukin-12 alpha subunit binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-23 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T-helper 1 cell cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T-helper cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to protozoan IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in interleukin-12-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in natural killer cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NK T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 1 type immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mononuclear cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV-B ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endosome lumen TAS
Traceable Author Statement
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of interleukin-12 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of interleukin-12 complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of interleukin-12 complex ISO
Inferred from Sequence Orthology
more info
 
part_of interleukin-23 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of interleukin-23 complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-12 subunit beta
Names
CLMF p40
IL-12 p40 subunit
IL-12 subunit p40
IL-23 subunit p40
cytotoxic lymphocyte maturation factor 40 kDa subunit
interleukin-12 p40 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303244.1NP_001290173.1  interleukin-12 subunit beta precursor

    See identical proteins and their annotated locations for NP_001290173.1

    Status: REVIEWED

    Source sequence(s)
    AL669944, BY154173, M86671
    Consensus CDS
    CCDS24563.1
    UniProtKB/Swiss-Prot
    P43432, Q9QUM1
    UniProtKB/TrEMBL
    Q3ZAX5
    Related
    ENSMUSP00000099860.4, ENSMUST00000102796.10
    Conserved Domains (3) summary
    smart00408
    Location:4290
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:4291
    IG_like; Immunoglobulin like
    pfam10420
    Location:123214
    IL12p40_C; Cytokine interleukin-12p40 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    44290890..44305504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_008352.2: Suppressed sequence

    Description
    NM_008352.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.