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Il12a interleukin 12a [ Mus musculus (house mouse) ]

Gene ID: 16159, updated on 25-Nov-2021

Summary

Official Symbol
Il12aprovided by MGI
Official Full Name
interleukin 12aprovided by MGI
Primary source
MGI:MGI:96539
See related
Ensembl:ENSMUSG00000027776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p35; Ll12a; Il-12a; IL-12p35
Expression
Biased expression in spleen adult (RPKM 2.9), lung adult (RPKM 1.2) and 8 other tissues See more
Orthologs
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Genomic context

See Il12a in Genome Data Viewer
Location:
3 E1; 3 31.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (68597977..68605883)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (68690644..68698550)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (68494566..68502469)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Iqcj and Schip1 fusion protein Neighboring gene schwannomin interacting protein 1 Neighboring gene uncharacterized LOC118568618 Neighboring gene predicted gene, 22073 Neighboring gene predicted gene, 35584 Neighboring gene spermine synthase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC151228, MGC151232

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cytokine activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-12 beta subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables interleukin-12 beta subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-12 receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-27 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T-helper 1 cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T-helper 1 cell cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to protozoan IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NK T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interferon-gamma production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mononuclear cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV-B ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endosome lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of interleukin-12 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of interleukin-12 complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of interleukin-12 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-12 subunit alpha
Names
CLMF p35
IL-12 p35 subunit
IL-12 subunit p35
cytotoxic lymphocyte maturation factor 35 kDa subunit
interleukin 12a p35 subunit
interleukin-12 p35 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159424.2NP_001152896.1  interleukin-12 subunit alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC121306, AK153729, M86672
    UniProtKB/Swiss-Prot
    P43431
    UniProtKB/TrEMBL
    F8WI71
    Related
    ENSMUSP00000029345.6, ENSMUST00000029345.12
    Conserved Domains (1) summary
    pfam03039
    Location:38236
    IL12; Interleukin-12 alpha subunit
  2. NM_008351.3NP_032377.1  interleukin-12 subunit alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_032377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC121306, AK153729, M86672
    Consensus CDS
    CCDS17400.1
    UniProtKB/Swiss-Prot
    P43431
    UniProtKB/TrEMBL
    Q549G3
    Related
    ENSMUSP00000103446.3, ENSMUST00000107816.4
    Conserved Domains (1) summary
    pfam03039
    Location:17215
    IL12; Interleukin-12 alpha subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    68597977..68605883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501044.5XP_006501107.1  interleukin-12 subunit alpha isoform X1

    Conserved Domains (1) summary
    pfam03039
    Location:2166
    IL12; Interleukin-12 alpha subunit
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