U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Il10ra interleukin 10 receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 16154, updated on 8-Feb-2024

Summary

Official Symbol
Il10raprovided by MGI
Official Full Name
interleukin 10 receptor, alphaprovided by MGI
Primary source
MGI:MGI:96538
See related
Ensembl:ENSMUSG00000032089 AllianceGenome:MGI:96538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il10r; CDw210; CDw210a; IL-10R1; IL-10RA; mIL-10R
Summary
Predicted to enable interleukin-10 binding activity and interleukin-10 receptor activity. Predicted to be involved in several processes, including negative regulation of autophagy; positive regulation of receptor signaling pathway via JAK-STAT; and ubiquitin-dependent endocytosis. Predicted to be located in cytosol. Predicted to be integral component of plasma membrane. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 28. Orthologous to human IL10RA (interleukin 10 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 30.8), thymus adult (RPKM 10.6) and 11 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Il10ra in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45165135..45180447, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45253837..45269149, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39327 Neighboring gene transmembrane protease, serine 4 Neighboring gene predicted gene, 57797 Neighboring gene small integral membrane protein 35 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45029701-45030002 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45054121-45054422 Neighboring gene microRNA 7086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45108641-45108750 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene transmembrane protease, serine 13 Neighboring gene STARR-seq mESC enhancer starr_23995 Neighboring gene FXYD domain-containing ion transport regulator 6 Neighboring gene predicted gene, 57798

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables interleukin-10 binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-10 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables interleukin-10 receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-10 receptor subunit alpha
Names
IL-10 receptor subunit alpha
IL-10R subunit 1
IL-10R subunit alpha
interleukin-10 receptor subunit 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324486.1NP_001311415.1  interleukin-10 receptor subunit alpha isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice donor site in the 5' coding region, compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK149680, AK149899, AK153120, BY691362
    Consensus CDS
    CCDS85671.1
    UniProtKB/TrEMBL
    H3BKN6, Q3UE89
    Related
    ENSMUSP00000135461.2, ENSMUST00000176222.2
  2. NM_008348.3NP_032374.1  interleukin-10 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_032374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK149899, AK159566, BY691362
    Consensus CDS
    CCDS23131.1
    UniProtKB/Swiss-Prot
    Q61727
    UniProtKB/TrEMBL
    Q3U6I9, Q3UDL4
    Related
    ENSMUSP00000034594.10, ENSMUST00000034594.16
    Conserved Domains (2) summary
    pfam01108
    Location:21114
    Tissue_fac; Tissue factor
    cl21522
    Location:132229
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_136903.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate 5' internal exon, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This transcript is potentially protein coding if an alternate upstream translational start codon is used.
    Source sequence(s)
    AK149899, AK153120, BY691362
    Related
    ENSMUST00000176808.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45165135..45180447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)