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NOP9 NOP9 nucleolar protein [ Homo sapiens (human) ]

Gene ID: 161424, updated on 5-Jul-2025
Official Symbol
NOP9provided by HGNC
Official Full Name
NOP9 nucleolar proteinprovided by HGNC
Primary source
HGNC:HGNC:19826
See related
Ensembl:ENSG00000196943 MIM:618308; AllianceGenome:HGNC:19826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HP08474; C14orf21
Summary
Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be part of 90S preribosome and preribosome, small subunit precursor. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in duodenum (RPKM 25.7), liver (RPKM 25.0) and 25 other tissues See more
Orthologs
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See NOP9 in Genome Data Viewer
Location:
14q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24271203..24309124)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18498194..18507467)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24769056..24778330)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24710068-24710597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8201 Neighboring gene Sharpr-MPRA regulatory region 7959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8202 Neighboring gene TERF1 interacting nuclear factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24727660-24728357 Neighboring gene transglutaminase 1 Neighboring gene TGM1 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8205 Neighboring gene Rab geranylgeranyltransferase subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8208 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:24747863-24748093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8213 Neighboring gene nonconserved acetylation island sequence 81 enhancer Neighboring gene dehydrogenase/reductase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5636 Neighboring gene cell death inducing DFFA like effector b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24785286-24785786 Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24790818-24791777 Neighboring gene adenylate cyclase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5639

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, chromosome 14 open reading frame 21, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • KIAA2021

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
nucleolar protein 9
Names
NOP9 nucleolar protein homolog
hypothetical protein HP08474
pumilio domain-containing protein C14orf21

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286367.2NP_001273296.1  nucleolar protein 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice sites in the coding region, which results a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB095941, AL096870, BC015481, BC025332, HY061279
    Consensus CDS
    CCDS66616.1
    UniProtKB/TrEMBL
    Q5HYL4
    Related
    ENSP00000380020.3, ENST00000396802.7
  2. NM_174913.3NP_777573.1  nucleolar protein 9 isoform 1

    See identical proteins and their annotated locations for NP_777573.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB095941, AL096870, BC015481, HY061279
    Consensus CDS
    CCDS9624.1
    UniProtKB/Swiss-Prot
    A8MY76, Q86U38, Q8IVF0, Q8TBS6
    UniProtKB/TrEMBL
    Q5HYL4
    Related
    ENSP00000267425.3, ENST00000267425.8
    Conserved Domains (1) summary
    cl21719
    Location:512600
    Pumilio; Pumilio-family RNA binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24271203..24309124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431054.1XP_047287010.1  nucleolar protein 9 isoform X1

    UniProtKB/TrEMBL
    Q5HYL4
  2. XM_047431053.1XP_047287009.1  nucleolar protein 9 isoform X1

    UniProtKB/TrEMBL
    Q5HYL4
  3. XM_047431052.1XP_047287008.1  nucleolar protein 9 isoform X1

    UniProtKB/TrEMBL
    Q5HYL4
  4. XM_047431055.1XP_047287011.1  nucleolar protein 9 isoform X1

    UniProtKB/TrEMBL
    Q5HYL4
  5. XM_005267385.2XP_005267442.1  nucleolar protein 9 isoform X1

    UniProtKB/TrEMBL
    Q5HYL4
    Conserved Domains (1) summary
    cl21719
    Location:526614
    Pumilio; Pumilio-family RNA binding domain
  6. XM_011536526.3XP_011534828.1  nucleolar protein 9 isoform X2

    UniProtKB/TrEMBL
    Q5HYL4
    Conserved Domains (1) summary
    cl21719
    Location:442530
    Pumilio; Pumilio-family RNA binding domain
  7. XM_011536527.3XP_011534829.1  nucleolar protein 9 isoform X3

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    600828..610102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332333.1XP_054188308.1  nucleolar protein 9 isoform X3

  2. XM_054332332.1XP_054188307.1  nucleolar protein 9 isoform X2

    UniProtKB/TrEMBL
    Q5HYL4
  3. XM_054332331.1XP_054188306.1  nucleolar protein 9 isoform X1

    UniProtKB/TrEMBL
    Q5HYL4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18498194..18507467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375515.1XP_054231490.1  nucleolar protein 9 isoform X3

  2. XM_054375514.1XP_054231489.1  nucleolar protein 9 isoform X2

    UniProtKB/TrEMBL
    Q5HYL4
  3. XM_054375513.1XP_054231488.1  nucleolar protein 9 isoform X1

    UniProtKB/TrEMBL
    Q5HYL4