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NOP9 NOP9 nucleolar protein [ Homo sapiens (human) ]

Gene ID: 161424, updated on 4-Dec-2022

Summary

Official Symbol
NOP9provided by HGNC
Official Full Name
NOP9 nucleolar proteinprovided by HGNC
Primary source
HGNC:HGNC:19826
See related
Ensembl:ENSG00000196943 MIM:618308; AllianceGenome:HGNC:19826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HP08474; C14orf21
Summary
Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be part of 90S preribosome and preribosome, small subunit precursor. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 25.7), liver (RPKM 25.0) and 25 other tissues See more
Orthologs
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Genomic context

See NOP9 in Genome Data Viewer
Location:
14q12
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24271203..24309124)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18498194..18507467)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24769056..24778330)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene TERF1 interacting nuclear factor 2 Neighboring gene transglutaminase 1 Neighboring gene TGM1 promoter region Neighboring gene Rab geranylgeranyltransferase subunit alpha Neighboring gene nonconserved acetylation island sequence 81 enhancer Neighboring gene dehydrogenase/reductase 1 Neighboring gene cell death inducing DFFA like effector b Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor Neighboring gene adenylate cyclase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, chromosome 14 open reading frame 21, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA2021

General protein information

Preferred Names
nucleolar protein 9
Names
NOP9 nucleolar protein homolog
hypothetical protein HP08474
pumilio domain-containing protein C14orf21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286367.2NP_001273296.1  nucleolar protein 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice sites in the coding region, which results a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB095941, AL096870, BC015481, BC025332, HY061279
    Consensus CDS
    CCDS66616.1
    UniProtKB/Swiss-Prot
    Q86U38
    Related
    ENSP00000380020.3, ENST00000396802.7
  2. NM_174913.3NP_777573.1  nucleolar protein 9 isoform 1

    See identical proteins and their annotated locations for NP_777573.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB095941, AL096870, BC015481, HY061279
    Consensus CDS
    CCDS9624.1
    UniProtKB/Swiss-Prot
    Q86U38, Q8TBS6
    Related
    ENSP00000267425.3, ENST00000267425.8
    Conserved Domains (1) summary
    cl21719
    Location:512600
    Pumilio; Pumilio-family RNA binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24271203..24309124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431054.1XP_047287010.1  nucleolar protein 9 isoform X1

  2. XM_047431053.1XP_047287009.1  nucleolar protein 9 isoform X1

  3. XM_047431052.1XP_047287008.1  nucleolar protein 9 isoform X1

  4. XM_047431055.1XP_047287011.1  nucleolar protein 9 isoform X1

  5. XM_005267385.2XP_005267442.1  nucleolar protein 9 isoform X1

    Conserved Domains (1) summary
    cl21719
    Location:526614
    Pumilio; Pumilio-family RNA binding domain
  6. XM_011536526.3XP_011534828.1  nucleolar protein 9 isoform X2

    Conserved Domains (1) summary
    cl21719
    Location:442530
    Pumilio; Pumilio-family RNA binding domain
  7. XM_011536527.3XP_011534829.1  nucleolar protein 9 isoform X3

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    600828..610102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18498194..18507467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)