Format

Send to:

Choose Destination

REM2 RRAD and GEM like GTPase 2 [ Homo sapiens (human) ]

Gene ID: 161253, updated on 13-Mar-2020

Summary

Official Symbol
REM2provided by HGNC
Official Full Name
RRAD and GEM like GTPase 2provided by HGNC
Primary source
HGNC:HGNC:20248
See related
Ensembl:ENSG00000139890 MIM:616955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in bone marrow (RPKM 2.3), spleen (RPKM 0.7) and 14 other tissues See more
Orthologs

Genomic context

See REM2 in Genome Data Viewer
Location:
14q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (22883165..22887678)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23352374..23356889)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 964 Neighboring gene LDL receptor related protein 10 Neighboring gene RNA binding motif protein 23 Neighboring gene PRMT5 antisense RNA 1 Neighboring gene protein arginine methyltransferase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38964

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GTP-binding protein REM 2
Names
RAS (RAD and GEM)-like GTP binding 2
RAS-like GTP binding 2
Rad and Gem-related 2 (rat homolog)
rad and Gem-like GTP-binding protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173527.3NP_775798.2  GTP-binding protein REM 2

    See identical proteins and their annotated locations for NP_775798.2

    Status: VALIDATED

    Source sequence(s)
    AK096283, AL135998, BC035663
    Consensus CDS
    CCDS45082.1
    UniProtKB/Swiss-Prot
    Q8IYK8
    Related
    ENSP00000267396.4, ENST00000267396.9
    Conserved Domains (2) summary
    cd04148
    Location:115340
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
    smart00173
    Location:115278
    RAS; Ras subfamily of RAS small GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    22883165..22887678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267383.3XP_005267440.1  GTP-binding protein REM 2 isoform X3

    Conserved Domains (2) summary
    cd04148
    Location:115341
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
    smart00173
    Location:115279
    RAS; Ras subfamily of RAS small GTPases
  2. XM_017021058.1XP_016876547.1  GTP-binding protein REM 2 isoform X1

  3. XM_017021059.1XP_016876548.1  GTP-binding protein REM 2 isoform X2

  4. XM_011536518.2XP_011534820.1  GTP-binding protein REM 2 isoform X4

    Conserved Domains (1) summary
    cl21455
    Location:147271
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Support Center