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REM2 RRAD and GEM like GTPase 2 [ Homo sapiens (human) ]

Gene ID: 161253, updated on 8-Feb-2025

Summary

Official Symbol
REM2provided by HGNC
Official Full Name
RRAD and GEM like GTPase 2provided by HGNC
Primary source
HGNC:HGNC:20248
See related
Ensembl:ENSG00000139890 MIM:616955; AllianceGenome:HGNC:20248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Feb 2025]
Expression
Broad expression in bone marrow (RPKM 2.3), spleen (RPKM 0.7) and 14 other tissues See more
Orthologs
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Genomic context

See REM2 in Genome Data Viewer
Location:
14q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (22883222..22887678)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17081280..17085738)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23352431..23356887)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23312200-23312700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23312701-23313201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23314693-23315218 Neighboring gene matrix metallopeptidase 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23315743-23316266 Neighboring gene Sharpr-MPRA regulatory region 964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5592 Neighboring gene LDL receptor related protein 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23352144-23352682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23352683-23353220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8149 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:23368929-23369666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8150 Neighboring gene RNA binding motif protein 23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23386410-23387174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5595 Neighboring gene PRMT5 antisense RNA 1 Neighboring gene protein arginine methyltransferase 5

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ38964

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
GTP-binding protein REM 2
Names
RAS (RAD and GEM)-like GTP binding 2
RAS-like GTP binding 2
Rad and Gem-related 2 (rat homolog)
rad and Gem-like GTP-binding protein 2
NP_775798.2
XP_005267440.1
XP_011534820.1
XP_016876547.1
XP_016876548.1
XP_047287001.1
XP_047287002.1
XP_047287003.1
XP_054231472.1
XP_054231473.1
XP_054231474.1
XP_054231475.1
XP_054231476.1
XP_054231477.1
XP_054231478.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173527.3NP_775798.2  GTP-binding protein REM 2

    See identical proteins and their annotated locations for NP_775798.2

    Status: VALIDATED

    Source sequence(s)
    AK096283, AL135998, BC035663
    Consensus CDS
    CCDS45082.1
    UniProtKB/Swiss-Prot
    B7Z5P1, Q8IYK8, Q8N8R8
    UniProtKB/TrEMBL
    A0A0S2Z647
    Related
    ENSP00000267396.4, ENST00000267396.9
    Conserved Domains (2) summary
    cd04148
    Location:115340
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
    smart00173
    Location:115278
    RAS; Ras subfamily of RAS small GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    22883222..22887678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267383.4XP_005267440.1  GTP-binding protein REM 2 isoform X5

    UniProtKB/TrEMBL
    A0A0S2Z647
    Conserved Domains (2) summary
    cd04148
    Location:115341
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
    smart00173
    Location:115279
    RAS; Ras subfamily of RAS small GTPases
  2. XM_047431045.1XP_047287001.1  GTP-binding protein REM 2 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z628
  3. XM_017021058.2XP_016876547.1  GTP-binding protein REM 2 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z647
  4. XM_011536518.3XP_011534820.1  GTP-binding protein REM 2 isoform X6

    Conserved Domains (1) summary
    cl21455
    Location:147271
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_017021059.2XP_016876548.1  GTP-binding protein REM 2 isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z647
  6. XM_047431047.1XP_047287003.1  GTP-binding protein REM 2 isoform X7

  7. XM_047431046.1XP_047287002.1  GTP-binding protein REM 2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17081280..17085738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375501.1XP_054231476.1  GTP-binding protein REM 2 isoform X5

    UniProtKB/TrEMBL
    A0A0S2Z647
  2. XM_054375499.1XP_054231474.1  GTP-binding protein REM 2 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z628
  3. XM_054375497.1XP_054231472.1  GTP-binding protein REM 2 isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z647
  4. XM_054375502.1XP_054231477.1  GTP-binding protein REM 2 isoform X6

  5. XM_054375498.1XP_054231473.1  GTP-binding protein REM 2 isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z647
  6. XM_054375503.1XP_054231478.1  GTP-binding protein REM 2 isoform X7

  7. XM_054375500.1XP_054231475.1  GTP-binding protein REM 2 isoform X4