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CLEC14A C-type lectin domain containing 14A [ Homo sapiens (human) ]

Gene ID: 161198, updated on 1-Jun-2020

Summary

Official Symbol
CLEC14Aprovided by HGNC
Official Full Name
C-type lectin domain containing 14Aprovided by HGNC
Primary source
HGNC:HGNC:19832
See related
Ensembl:ENSG00000176435 MIM:616845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEG1; EGFR-5; C14orf27
Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]
Orthologs

Genomic context

See CLEC14A in Genome Data Viewer
Location:
14q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (38254000..38256093, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (38723205..38725575, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370456 Neighboring gene uncharacterized LOC112268136 Neighboring gene somatostatin receptor 1 Neighboring gene general transcription factor IIH subunit 3 pseudogene Neighboring gene keratin 8 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-type lectin domain family 14 member A
Names
ClECT and EGF-like domain containing protein
epidermal growth factor receptor 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175060.3NP_778230.1  C-type lectin domain family 14 member A precursor

    See identical proteins and their annotated locations for NP_778230.1

    Status: REVIEWED

    Source sequence(s)
    AY358395, AY606132
    Consensus CDS
    CCDS9667.1
    UniProtKB/Swiss-Prot
    Q86T13
    Related
    ENSP00000353013.2, ENST00000342213.3
    Conserved Domains (2) summary
    cd03600
    Location:32175
    CLECT_thrombomodulin_like; C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR
    pfam14670
    Location:254286
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    38254000..38256093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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