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DAP death associated protein [ Homo sapiens (human) ]

Gene ID: 1611, updated on 24-Nov-2020

Summary

Official Symbol
DAPprovided by HGNC
Official Full Name
death associated proteinprovided by HGNC
Primary source
HGNC:HGNC:2672
See related
Ensembl:ENSG00000112977 MIM:600954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in thyroid (RPKM 62.5), urinary bladder (RPKM 56.2) and 25 other tissues See more
Orthologs

Genomic context

See DAP in Genome Data Viewer
Location:
5p15.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (10679230..10761234, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (10679342..10761387, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 33B Neighboring gene Sharpr-MPRA regulatory region 12583 Neighboring gene intersectin 1 (SH3 domain protein) pseudogene Neighboring gene uncharacterized CTD-2154B17.1 Neighboring gene DAP divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99796

Gene Ontology Provided by GOA

Function Evidence Code Pubs
death domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
death domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
death-associated protein 1
Names
DAP-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011546.1 RefSeqGene

    Range
    5042..87046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001291963.2NP_001278892.1  death-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001278892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC002726, BI823002, DC395850
    Consensus CDS
    CCDS77997.1
    UniProtKB/Swiss-Prot
    P51397
    UniProtKB/TrEMBL
    B4DQ75
    Related
    ENSP00000394163.2, ENST00000432074.2
    Conserved Domains (1) summary
    pfam15228
    Location:12179
    DAP; Death-associated protein
  2. NM_004394.3NP_004385.1  death-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_004385.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in the coding region, which causes a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC002726, BP265421, DC395850
    Consensus CDS
    CCDS3880.1
    UniProtKB/Swiss-Prot
    P51397
    Related
    ENSP00000230895.6, ENST00000230895.10
    Conserved Domains (1) summary
    pfam15228
    Location:12102
    DAP; Death-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    10679230..10761234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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