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STOML3 stomatin like 3 [ Homo sapiens (human) ]

Gene ID: 161003, updated on 22-Sep-2022

Summary

Official Symbol
STOML3provided by HGNC
Official Full Name
stomatin like 3provided by HGNC
Primary source
HGNC:HGNC:19420
See related
Ensembl:ENSG00000133115 MIM:608327; AllianceGenome:HGNC:19420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRO; Epb7.2l
Summary
Predicted to act upstream of or within signal transduction. Predicted to be located in cilium and membrane raft. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung (RPKM 1.0), endometrium (RPKM 0.3) and 2 other tissues See more
Orthologs
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Genomic context

See STOML3 in Genome Data Viewer
Location:
13q13.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (38965925..38990831, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (38185480..38210474, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (39540062..39564968, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group XIIA pseudogene 2 Neighboring gene ankyrin repeat domain 26 pseudogene 2 Neighboring gene proline and serine rich 1 Neighboring gene NHL repeat containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
stomatin-like protein 3
Names
EPB72-like 3
SLP-3
erythrocyte band 7 integral membrane protein
protein 7.2B
stomatin (EPB72)-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144033.2NP_001137505.1  stomatin-like protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001137505.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame coding exon compared to transcript variant 1. This results in translation initiation from a downstream AUG found in this novel exon, and a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK304159, BC025760, BM982114, DB200356
    Consensus CDS
    CCDS45040.1
    UniProtKB/Swiss-Prot
    Q8TAV4
    Related
    ENSP00000401989.1, ENST00000423210.1
    Conserved Domains (1) summary
    cl19107
    Location:64262
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  2. NM_145286.3NP_660329.1  stomatin-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_660329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC025760, BM982114
    Consensus CDS
    CCDS9367.1
    UniProtKB/Swiss-Prot
    Q5JS35, Q8TAV4
    Related
    ENSP00000368952.4, ENST00000379631.9
    Conserved Domains (1) summary
    cl19107
    Location:73271
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    38965925..38990831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020400.1XP_016875889.1  stomatin-like protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    38185480..38210474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)