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GPR180 G protein-coupled receptor 180 [ Homo sapiens (human) ]

Gene ID: 160897, updated on 12-Oct-2019

Summary

Official Symbol
GPR180provided by HGNC
Official Full Name
G protein-coupled receptor 180provided by HGNC
Primary source
HGNC:HGNC:28899
See related
Ensembl:ENSG00000152749 MIM:607787
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ITR
Summary
This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 4.6), thyroid (RPKM 2.7) and 25 other tissues See more
Orthologs

Genomic context

See GPR180 in Genome Data Viewer
Location:
13q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (94601857..94634661)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (95254104..95286899)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene tRNA-Phe (anticodon GAA) 1-5 Neighboring gene TDP-glucose 4,6-dehydratase Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 5 Neighboring gene RNA, 5S ribosomal pseudogene 36 Neighboring gene VISTA enhancer hs796

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586C1322, DKFZp667K0825

Gene Ontology Provided by GOA

Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to pheromone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
integral membrane protein GPR180
Names
intimal thickness-related receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_180989.6NP_851320.1  integral membrane protein GPR180 precursor

    See identical proteins and their annotated locations for NP_851320.1

    Status: REVIEWED

    Source sequence(s)
    AL049452, AL359708, BC052243, CD110068, DB150630
    Consensus CDS
    CCDS9472.1
    UniProtKB/Swiss-Prot
    Q86V85
    Related
    ENSP00000366157.4, ENST00000376958.5
    Conserved Domains (1) summary
    pfam10192
    Location:141405
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    94601857..94634661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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