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DGKG diacylglycerol kinase gamma [ Homo sapiens (human) ]

Gene ID: 1608, updated on 21-Dec-2019

Summary

Official Symbol
DGKGprovided by HGNC
Official Full Name
diacylglycerol kinase gammaprovided by HGNC
Primary source
HGNC:HGNC:2853
See related
Ensembl:ENSG00000058866 MIM:601854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAGK3; DGK-GAMMA
Summary
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 8.0), heart (RPKM 3.6) and 15 other tissues See more
Orthologs

Genomic context

See DGKG in Genome Data Viewer
Location:
3q27.2-q27.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (186147201..186362234, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185852896..186080023, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ETS variant transcription factor 5 Neighboring gene uncharacterized LOC105374257 Neighboring gene long intergenic non-protein coding RNA 2020 Neighboring gene long intergenic non-protein coding RNA 2052 Neighboring gene long intergenic non-protein coding RNA 2051

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ETV5

Homology

Clone Names

  • MGC104993, MGC133330

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
neuron development IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
diacylglycerol kinase gamma
Names
DAG kinase gamma
diacylglycerol kinase, gamma 90kDa
diacylglyerol kinase gamma
diglyceride kinase gamma
NP_001074213.1
NP_001074214.1
NP_001337.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080744.2NP_001074213.1  diacylglycerol kinase gamma isoform 2

    See identical proteins and their annotated locations for NP_001074213.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a protein (isoform 2) that is shorter than isoform 1.
    Source sequence(s)
    AC112649, AC117414, BC089411, BM669549
    Consensus CDS
    CCDS43182.1
    UniProtKB/Swiss-Prot
    P49619
    Related
    ENSP00000339777.4, ENST00000344484.8
    Conserved Domains (7) summary
    smart00109
    Location:336377
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00045
    Location:553727
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:436532
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:272321
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:179248
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:180244
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:5175
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  2. NM_001080745.2NP_001074214.1  diacylglycerol kinase gamma isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a protein (isoform 3) that is shorter than isoform 1.
    Source sequence(s)
    AC112649, AC117414, BC089411, BC112363, BM669549
    Consensus CDS
    CCDS43181.1
    UniProtKB/Swiss-Prot
    P49619
    Related
    ENSP00000371599.4, ENST00000382164.8
    Conserved Domains (6) summary
    smart00045
    Location:539713
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:397518
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:272321
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:179248
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:180244
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:5175
    DAG_kinase_N; Diacylglycerol kinase N-terminus
  3. NM_001346.3NP_001337.2  diacylglycerol kinase gamma isoform 1

    See identical proteins and their annotated locations for NP_001337.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC112649, AC117414, BC089411, BM669549, D26135
    Consensus CDS
    CCDS3274.1
    UniProtKB/Swiss-Prot
    P49619
    Related
    ENSP00000265022.3, ENST00000265022.8
    Conserved Domains (7) summary
    smart00109
    Location:336377
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00045
    Location:578752
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:436557
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:272321
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:179248
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:180244
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:5175
    DAG_kinase_N; Diacylglycerol kinase N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    186147201..186362234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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