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PPTC7 protein phosphatase targeting COQ7 [ Homo sapiens (human) ]

Gene ID: 160760, updated on 13-Mar-2020

Summary

Official Symbol
PPTC7provided by HGNC
Official Full Name
protein phosphatase targeting COQ7provided by HGNC
Primary source
HGNC:HGNC:30695
See related
Ensembl:ENSG00000196850 MIM:609668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAPP2C; TA-PP2C
Expression
Ubiquitous expression in bone marrow (RPKM 18.8), heart (RPKM 15.4) and 25 other tissues See more
Orthologs

Genomic context

See PPTC7 in Genome Data Viewer
Location:
12q24.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (110533245..110583318, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110972237..111021064, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene GPN-loop GTPase 3 Neighboring gene family with sequence similarity 216 member A Neighboring gene VPS29 retromer complex component Neighboring gene RAD9 checkpoint clamp component B Neighboring gene HNF4 motif-containing MPRA enhancer 250 Neighboring gene RNA, 7SL, cytoplasmic 387, pseudogene Neighboring gene tectonic family member 1 Neighboring gene hydrogen voltage gated channel 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133072, DKFZp686M07120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
peptidyl-serine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase PTC7 homolog
Names
PTC7 protein phosphatase homolog
NP_644812.1
XP_024304637.1
XP_024304638.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139283.2NP_644812.1  protein phosphatase PTC7 homolog

    See identical proteins and their annotated locations for NP_644812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AC002350, AF385435
    Consensus CDS
    CCDS9149.1
    UniProtKB/Swiss-Prot
    Q8NI37
    Related
    ENSP00000346255.3, ENST00000354300.5
    Conserved Domains (1) summary
    cl00120
    Location:60296
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RNA

  1. NR_138550.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC002350

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    110533245..110583318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448869.1XP_024304637.1  protein phosphatase PTC7 homolog isoform X1

    Conserved Domains (1) summary
    cl00120
    Location:60240
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  2. XM_024448870.1XP_024304638.1  protein phosphatase PTC7 homolog isoform X2

    Conserved Domains (1) summary
    cl00120
    Location:60240
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
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