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SLC5A8 solute carrier family 5 member 8 [ Homo sapiens (human) ]

Gene ID: 160728, updated on 4-Dec-2023

Summary

Official Symbol
SLC5A8provided by HGNC
Official Full Name
solute carrier family 5 member 8provided by HGNC
Primary source
HGNC:HGNC:19119
See related
Ensembl:ENSG00000256870 MIM:608044; AllianceGenome:HGNC:19119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIT; SMCT; SMCT1
Summary
SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]
Expression
Biased expression in thyroid (RPKM 19.8), kidney (RPKM 2.8) and 1 other tissue See more
Orthologs
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Genomic context

See SLC5A8 in Genome Data Viewer
Location:
12q23.1-q23.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (101155493..101210238, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (101117226..101171943, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (101549271..101604016, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene growth arrest specific 2 like 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class A pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:101055348-101055876 Neighboring gene anoctamin 4 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:101380545-101381070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:101382123-101382646 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:101411804-101413003 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:101495121-101495326 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_22530 Neighboring gene sorting nexin 5 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:101588413-101588600 Neighboring gene RNA, U6 small nuclear 768, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:101673582-101674173 Neighboring gene ribosomal protein S6 pseudogene 19 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:101693090-101694289 Neighboring gene UTP20 small subunit processome component Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC125354

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
 
involved_in acetate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in iodide transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lactate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lactate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic ion transport TAS
Traceable Author Statement
more info
 
involved_in nicotinate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nitrate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in propanoate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in propanoate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyruvate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of GINS complex IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium-coupled monocarboxylate transporter 1
Names
apical iodide transporter
electrogenic sodium monocarboxylate cotransporter
sodium iodide-related cotransporter
solute carrier family 5 (iodide transporter), member 8
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145913.5NP_666018.3  sodium-coupled monocarboxylate transporter 1

    See identical proteins and their annotated locations for NP_666018.3

    Status: VALIDATED

    Source sequence(s)
    AC079953, BC110492, DB229173
    Consensus CDS
    CCDS9080.1
    UniProtKB/Swiss-Prot
    Q2TB99, Q7Z2H9, Q8N695
    UniProtKB/TrEMBL
    B2R9H8
    Related
    ENSP00000445340.2, ENST00000536262.3
    Conserved Domains (1) summary
    cd11519
    Location:7549
    SLC5sbd_SMCT1; Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    101155493..101210238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018910.3XP_016874399.1  sodium-coupled monocarboxylate transporter 1 isoform X1

RNA

  1. XR_007063055.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315942.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    48058..102804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329566.1XP_054185541.1  sodium-coupled monocarboxylate transporter 1 isoform X1

RNA

  1. XR_008485650.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    101117226..101171943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371292.1XP_054227267.1  sodium-coupled monocarboxylate transporter 1 isoform X1

RNA

  1. XR_008488548.1 RNA Sequence