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SLC5A8 solute carrier family 5 member 8 [ Homo sapiens (human) ]

Gene ID: 160728, updated on 7-Jun-2020

Summary

Official Symbol
SLC5A8provided by HGNC
Official Full Name
solute carrier family 5 member 8provided by HGNC
Primary source
HGNC:HGNC:19119
See related
Ensembl:ENSG00000256870 MIM:608044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIT; SMCT; SMCT1
Summary
SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]
Expression
Biased expression in thyroid (RPKM 19.8), kidney (RPKM 2.8) and 1 other tissue See more
Orthologs

Genomic context

See SLC5A8 in Genome Data Viewer
Location:
12q23.1-q23.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (101155493..101210238, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (101549994..101604016, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene growth arrest specific 2 like 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class A pseudogene 1 Neighboring gene anoctamin 4 Neighboring gene sorting nexin 5 pseudogene 2 Neighboring gene RNA, U6 small nuclear 768, pseudogene Neighboring gene ribosomal protein S6 pseudogene 19 Neighboring gene UTP20 small subunit processome component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125354

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lactate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
monocarboxylate:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
 
monocarboxylic acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
organic acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
passive transmembrane transporter activity TAS
Traceable Author Statement
more info
 
propionate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
ion transport TAS
Traceable Author Statement
more info
 
lactate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
propanoate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
short-chain fatty acid import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium-coupled monocarboxylate transporter 1
Names
apical iodide transporter
electrogenic sodium monocarboxylate cotransporter
sodium iodide-related cotransporter
solute carrier family 5 (iodide transporter), member 8
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145913.5NP_666018.3  sodium-coupled monocarboxylate transporter 1

    See identical proteins and their annotated locations for NP_666018.3

    Status: VALIDATED

    Source sequence(s)
    AC079953, BC110492, DB229173
    Consensus CDS
    CCDS9080.1
    UniProtKB/Swiss-Prot
    Q8N695
    Related
    ENSP00000445340.2, ENST00000536262.3
    Conserved Domains (1) summary
    cd11519
    Location:7549
    SLC5sbd_SMCT1; Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    101155493..101210238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018910.2XP_016874399.1  sodium-coupled monocarboxylate transporter 1 isoform X1

RNA

  1. XR_944503.3 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315942.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    48058..102804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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