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DENND5B DENN domain containing 5B [ Homo sapiens (human) ]

Gene ID: 160518, updated on 23-Nov-2021

Summary

Official Symbol
DENND5Bprovided by HGNC
Official Full Name
DENN domain containing 5Bprovided by HGNC
Primary source
HGNC:HGNC:28338
See related
Ensembl:ENSG00000170456 MIM:617279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in ovary (RPKM 8.9), testis (RPKM 6.8) and 21 other tissues See more
Orthologs
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Genomic context

See DENND5B in Genome Data Viewer
Location:
12p11.21
Exon count:
26
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (31382226..31591136, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31535160..31744070, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SIN3-HDAC complex associated factor Neighboring gene uncharacterized LOC79857 Neighboring gene long intergenic non-protein coding RNA 2387 Neighboring gene RNA, U6 small nuclear 618, pseudogene Neighboring gene TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa pseudogene Neighboring gene mitochondrial ribosomal protein L30 pseudogene 2 Neighboring gene ANKRD49 pseudogene 2 Neighboring gene DENND5B antisense RNA 1 Neighboring gene RNA, U5F small nuclear 4, pseudogene Neighboring gene ribosomal protein L31 pseudogene 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41648, FLJ43333, MGC24039, DKFZp686P1174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in positive regulation of triglyceride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DENN domain-containing protein 5B
Names
DENN/MADD domain containing 5B
rab6IP1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308339.2NP_001295268.1  DENN domain-containing protein 5B isoform 2

    See identical proteins and their annotated locations for NP_001295268.1

    Status: VALIDATED

    Source sequence(s)
    AC022080, AC068792, AK125323, BC068580, BM676905
    Consensus CDS
    CCDS76542.1
    UniProtKB/Swiss-Prot
    Q6ZUT9
    UniProtKB/TrEMBL
    G3V1S3
    Related
    ENSP00000444889.1, ENST00000536562.5
    Conserved Domains (6) summary
    smart00801
    Location:534609
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:82155
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:9711079
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:222410
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:815959
    RUN; RUN domain
    cl02689
    Location:11621299
    RUN; RUN domain
  2. NM_001366890.1NP_001353819.1  DENN domain-containing protein 5B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022080, AC068792
    Related
    ENSP00000346238.4, ENST00000354285.8
    Conserved Domains (3) summary
    smart00801
    Location:521596
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:19142
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:209397
    DENN; DENN (AEX-3) domain
  3. NM_001366891.1NP_001353820.1  DENN domain-containing protein 5B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC022080, AC068792
  4. NM_001366892.1NP_001353821.1  DENN domain-containing protein 5B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC022080, AC068792
    Related
    ENSP00000442938.1, ENST00000546299.1
    Conserved Domains (2) summary
    smart00800
    Location:19120
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:187375
    DENN; DENN (AEX-3) domain
  5. NM_001366893.1NP_001353822.1  DENN domain-containing protein 5B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC022080, AC068792
    Conserved Domains (2) summary
    smart00800
    Location:19142
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:209397
    DENN; DENN (AEX-3) domain
  6. NM_144973.4NP_659410.3  DENN domain-containing protein 5B isoform 1

    See identical proteins and their annotated locations for NP_659410.3

    Status: VALIDATED

    Source sequence(s)
    AB209341, AC022080, AC068792, AI762929, BC020855, BF513808, BM676905
    Consensus CDS
    CCDS44857.1
    UniProtKB/Swiss-Prot
    Q6ZUT9
    Related
    ENSP00000373734.5, ENST00000389082.10
    Conserved Domains (6) summary
    smart00801
    Location:499574
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:19120
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:9361044
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:187375
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:780924
    RUN; RUN domain
    cl02689
    Location:11271264
    RUN; RUN domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    31382226..31591136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018896.1XP_016874385.1  DENN domain-containing protein 5B isoform X4

  2. XM_005253326.2XP_005253383.1  DENN domain-containing protein 5B isoform X1

    Conserved Domains (6) summary
    smart00801
    Location:521596
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:19142
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:9951103
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:209397
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:839983
    RUN; RUN domain
    cl02689
    Location:11861323
    RUN; RUN domain
  3. XM_005253327.3XP_005253384.1  DENN domain-containing protein 5B isoform X2

    Conserved Domains (6) summary
    smart00801
    Location:499574
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:19120
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:9731081
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:187375
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:817961
    RUN; RUN domain
    cl02689
    Location:11641301
    RUN; RUN domain
  4. XM_005253330.3XP_005253387.1  DENN domain-containing protein 5B isoform X6

    Conserved Domains (6) summary
    smart00801
    Location:344419
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:146220
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:19142
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:818926
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02759
    Location:662806
    RUN; RUN domain
    cl02689
    Location:10091146
    RUN; RUN domain
  5. XM_017018898.1XP_016874387.1  DENN domain-containing protein 5B isoform X7

  6. XM_006719040.3XP_006719103.1  DENN domain-containing protein 5B isoform X3

    See identical proteins and their annotated locations for XP_006719103.1

    Conserved Domains (6) summary
    smart00801
    Location:521596
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:19142
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:9581066
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:209397
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:802946
    RUN; RUN domain
    cl02689
    Location:11491286
    RUN; RUN domain
  7. XM_017018897.1XP_016874386.1  DENN domain-containing protein 5B isoform X5

  8. XM_017018899.1XP_016874388.1  DENN domain-containing protein 5B isoform X8

  9. XM_011520590.2XP_011518892.1  DENN domain-containing protein 5B isoform X9

    Conserved Domains (5) summary
    smart00801
    Location:226301
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:24102
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cd01757
    Location:700808
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02759
    Location:544688
    RUN; RUN domain
    cl02689
    Location:8911028
    RUN; RUN domain
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