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LDHAL6A lactate dehydrogenase A like 6A [ Homo sapiens (human) ]

Gene ID: 160287, updated on 1-Jun-2020

Summary

Official Symbol
LDHAL6Aprovided by HGNC
Official Full Name
lactate dehydrogenase A like 6Aprovided by HGNC
Primary source
HGNC:HGNC:28335
See related
Ensembl:ENSG00000166800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDH6A
Expression
Biased expression in testis (RPKM 3.4) and thyroid (RPKM 0.2) See more
Orthologs

Genomic context

See LDHAL6A in Genome Data Viewer
Location:
11p15.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (18455856..18479601)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18477374..18501814)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A Neighboring gene lactate dehydrogenase C Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta pseudogene 2 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene Sharpr-MPRA regulatory region 13786

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-lactate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
L-lactate dehydrogenase A-like 6A
NP_001137543.1
NP_659409.2
XP_005252862.2
XP_011518224.1
XP_011518225.1
XP_011518226.1
XP_011518227.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144071.2NP_001137543.1  L-lactate dehydrogenase A-like 6A

    See identical proteins and their annotated locations for NP_001137543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AC027544, AY581313
    Consensus CDS
    CCDS7841.1
    UniProtKB/Swiss-Prot
    Q6ZMR3
    Related
    ENSP00000379516.3, ENST00000396213.7
    Conserved Domains (1) summary
    cd05293
    Location:19329
    LDH_1; A subgroup of L-lactate dehydrogenases
  2. NM_144972.5NP_659409.2  L-lactate dehydrogenase A-like 6A

    See identical proteins and their annotated locations for NP_659409.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC027544, AY581313
    Consensus CDS
    CCDS7841.1
    UniProtKB/Swiss-Prot
    Q6ZMR3
    Related
    ENSP00000280706.2, ENST00000280706.3
    Conserved Domains (1) summary
    cd05293
    Location:19329
    LDH_1; A subgroup of L-lactate dehydrogenases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    18455856..18479601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519923.2XP_011518225.1  L-lactate dehydrogenase A-like 6A isoform X3

    See identical proteins and their annotated locations for XP_011518225.1

    Conserved Domains (2) summary
    cd05293
    Location:19347
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25343
    L-LDH-NAD; L-lactate dehydrogenase
  2. XM_011519922.2XP_011518224.1  L-lactate dehydrogenase A-like 6A isoform X1

    Conserved Domains (2) summary
    cd05293
    Location:43371
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:49367
    L-LDH-NAD; L-lactate dehydrogenase
  3. XM_005252805.4XP_005252862.2  L-lactate dehydrogenase A-like 6A isoform X2

    Conserved Domains (2) summary
    cd05293
    Location:43353
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:49349
    L-LDH-NAD; L-lactate dehydrogenase
  4. XM_011519924.2XP_011518226.1  L-lactate dehydrogenase A-like 6A isoform X3

    See identical proteins and their annotated locations for XP_011518226.1

    Conserved Domains (2) summary
    cd05293
    Location:19347
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25343
    L-LDH-NAD; L-lactate dehydrogenase
  5. XM_011519925.1XP_011518227.1  L-lactate dehydrogenase A-like 6A isoform X3

    See identical proteins and their annotated locations for XP_011518227.1

    Conserved Domains (2) summary
    cd05293
    Location:19347
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25343
    L-LDH-NAD; L-lactate dehydrogenase
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