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LDHAL6A lactate dehydrogenase A like 6A [ Homo sapiens (human) ]

Gene ID: 160287, updated on 3-May-2025
Official Symbol
LDHAL6Aprovided by HGNC
Official Full Name
lactate dehydrogenase A like 6Aprovided by HGNC
Primary source
HGNC:HGNC:28335
See related
Ensembl:ENSG00000166800 MIM:618928; AllianceGenome:HGNC:28335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDH6A
Summary
Enables L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in testis (RPKM 3.4) and thyroid (RPKM 0.2) See more
Orthologs
all
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See LDHAL6A in Genome Data Viewer
Location:
11p15.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18455856..18479601)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18553931..18577621)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18477403..18501148)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18416070-18416735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3191 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:18417470-18417971 Neighboring gene lactate dehydrogenase A Neighboring gene lactate dehydrogenase C Neighboring gene ReSE screen-validated silencer GRCh37_chr11:18507685-18507894 Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4502 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene ReSE screen-validated silencer GRCh37_chr11:18600575-18600756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4505 Neighboring gene Sharpr-MPRA regulatory region 13786

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA). Chen X, et al. Mol Biol Rep, 2009 Apr. PMID 18351441
  2. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. Kaltenbach LS, et al. PLoS Genet, 2007 May 11. PMID 17500595, Free PMC Article
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  4. ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Pankow S, et al. Nature, 2015 Dec 24. PMID 26618866, Free PMC Article
  5. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Malty RH, et al. Cell Syst, 2017 Dec 27. PMID 29128334, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression of LDHAL6A was able to activate transcriptional activities of AP1(PMA)
    Title: Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA).
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC23940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lactate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-lactate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lactate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
L-lactate dehydrogenase A-like 6A
Names
LDHA-like protein 6A
NP_001137543.1
NP_659409.2
XP_005252862.2
XP_011518224.2
XP_011518225.1
XP_011518226.1
XP_011518227.1
XP_054223838.1
XP_054223839.1
XP_054223840.1
XP_054223841.1
XP_054223842.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144071.2 → NP_001137543.1  L-lactate dehydrogenase A-like 6A

    See identical proteins and their annotated locations for NP_001137543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AC027544, AY581313
    Consensus CDS
    CCDS7841.1
    UniProtKB/Swiss-Prot
    D3DQY5, Q6ZMR3
    Related
    ENSP00000379516.3, ENST00000396213.7
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

  2. NM_144972.5 → NP_659409.2  L-lactate dehydrogenase A-like 6A

    See identical proteins and their annotated locations for NP_659409.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC027544, AY581313
    Consensus CDS
    CCDS7841.1
    UniProtKB/Swiss-Prot
    D3DQY5, Q6ZMR3
    Related
    ENSP00000280706.2, ENST00000280706.3
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18455856..18479601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519923.3 → XP_011518225.1  L-lactate dehydrogenase A-like 6A isoform X3

    See identical proteins and their annotated locations for XP_011518225.1

    Conserved Domains (2) summary
    cd05293
    Location:19 → 347
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25 → 343
    L-LDH-NAD; L-lactate dehydrogenase

  2. XM_011519922.3 → XP_011518224.2  L-lactate dehydrogenase A-like 6A isoform X1

  3. XM_005252805.5 → XP_005252862.2  L-lactate dehydrogenase A-like 6A isoform X2

    Conserved Domains (2) summary
    cd05293
    Location:43 → 353
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:49 → 349
    L-LDH-NAD; L-lactate dehydrogenase

  4. XM_011519925.2 → XP_011518227.1  L-lactate dehydrogenase A-like 6A isoform X3

    See identical proteins and their annotated locations for XP_011518227.1

    Conserved Domains (2) summary
    cd05293
    Location:19 → 347
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25 → 343
    L-LDH-NAD; L-lactate dehydrogenase

  5. XM_011519924.3 → XP_011518226.1  L-lactate dehydrogenase A-like 6A isoform X3

    See identical proteins and their annotated locations for XP_011518226.1

    Conserved Domains (2) summary
    cd05293
    Location:19 → 347
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25 → 343
    L-LDH-NAD; L-lactate dehydrogenase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    18553931..18577621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367865.1 → XP_054223840.1  L-lactate dehydrogenase A-like 6A isoform X3

  2. XM_054367863.1 → XP_054223838.1  L-lactate dehydrogenase A-like 6A isoform X1

  3. XM_054367864.1 → XP_054223839.1  L-lactate dehydrogenase A-like 6A isoform X2

  4. XM_054367867.1 → XP_054223842.1  L-lactate dehydrogenase A-like 6A isoform X3

  5. XM_054367866.1 → XP_054223841.1  L-lactate dehydrogenase A-like 6A isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZMR3.1 GenPept UniProtKB/Swiss-Prot:Q6ZMR3

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