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C11orf65 chromosome 11 open reading frame 65 [ Homo sapiens (human) ]

Gene ID: 160140, updated on 13-May-2022

Summary

Official Symbol
C11orf65provided by HGNC
Official Full Name
chromosome 11 open reading frame 65provided by HGNC
Primary source
HGNC:HGNC:28519
See related
Ensembl:ENSG00000166323 AllianceGenome:HGNC:28519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MFI
Summary
Predicted to be involved in negative regulation of mitochondrial fission and negative regulation of protein targeting to mitochondrion. Predicted to be located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 4.7), lymph node (RPKM 0.9) and 11 other tissues See more
Orthologs
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Genomic context

See C11orf65 in Genome Data Viewer
Location:
11q22.3
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (108308519..108469881, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (108316028..108475012, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (108179246..108338256, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene acetyl-CoA acetyltransferase 1 Neighboring gene nuclear protein, coactivator of histone transcription Neighboring gene ATM serine/threonine kinase Neighboring gene uncharacterized LOC124902749 Neighboring gene uncharacterized LOC112267909 Neighboring gene protein O-glucosyltransferase 3 Neighboring gene exophilin 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
EBI GWAS Catalog
Does metformin work for everyone? A genome-wide association study for metformin response.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33948

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein MFI
Names
mitochondrial fission factor interactor
uncharacterized protein C11orf65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054724.1 RefSeqGene

    Range
    7304..92078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330368.2NP_001317297.1  protein MFI isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK303096
    Consensus CDS
    CCDS81622.1
    UniProtKB/Swiss-Prot
    Q8NCR3
    Related
    ENSP00000433395.1, ENST00000525729.5
  2. NM_001351110.2NP_001338039.1  protein MFI isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001925, AP005718
  3. NM_152587.5NP_689800.3  protein MFI isoform 1

    See identical proteins and their annotated locations for NP_689800.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AP005718, BC029536, DB104722
    Consensus CDS
    CCDS8340.1
    UniProtKB/Swiss-Prot
    Q8NCR3
    UniProtKB/TrEMBL
    A0A024R3C9
    Related
    ENSP00000376799.1, ENST00000393084.6

RNA

  1. NR_147053.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP005718

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    108308519..108469881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426461.1XP_047282417.1  protein MFI isoform X1

  2. XM_047426467.1XP_047282423.1  protein MFI isoform X7

  3. XM_047426463.1XP_047282419.1  protein MFI isoform X3

  4. XM_047426473.1XP_047282429.1  protein MFI isoform X14

  5. XM_047426462.1XP_047282418.1  protein MFI isoform X2

  6. XM_047426459.1XP_047282415.1  protein MFI isoform X1

  7. XM_047426458.1XP_047282414.1  protein MFI isoform X1

  8. XM_047426466.1XP_047282422.1  protein MFI isoform X6

  9. XM_047426460.1XP_047282416.1  protein MFI isoform X1

  10. XM_047426471.1XP_047282427.1  protein MFI isoform X12

  11. XM_047426470.1XP_047282426.1  protein MFI isoform X11

  12. XM_047426476.1XP_047282432.1  protein MFI isoform X17

  13. XM_047426477.1XP_047282433.1  protein MFI isoform X18

  14. XM_011542643.3XP_011540945.1  protein MFI isoform X16

  15. XM_047426469.1XP_047282425.1  protein MFI isoform X10

  16. XM_047426464.1XP_047282420.1  protein MFI isoform X4

  17. XM_047426478.1XP_047282434.1  protein MFI isoform X19

  18. XM_047426474.1XP_047282430.1  protein MFI isoform X15

  19. XM_011542641.3XP_011540943.1  protein MFI isoform X13

    See identical proteins and their annotated locations for XP_011540943.1

  20. XM_005271413.4XP_005271470.1  protein MFI isoform X9

  21. XM_005271412.4XP_005271469.1  protein MFI isoform X5

    See identical proteins and their annotated locations for XP_005271469.1

  22. XM_047426472.1XP_047282428.1  protein MFI isoform X13

  23. XM_047426465.1XP_047282421.1  protein MFI isoform X5

  24. XM_047426468.1XP_047282424.1  protein MFI isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    108316028..108475012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)