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Igf2 insulin-like growth factor 2 [ Mus musculus (house mouse) ]

Gene ID: 16002, updated on 5-Mar-2024

Summary

Official Symbol
Igf2provided by MGI
Official Full Name
insulin-like growth factor 2provided by MGI
Primary source
MGI:MGI:96434
See related
Ensembl:ENSMUSG00000048583 AllianceGenome:MGI:96434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpr; M6pr; Peg2; Igf-2; Igf-II
Summary
This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Expression
Biased expression in limb E14.5 (RPKM 601.7), liver E18 (RPKM 468.8) and 7 other tissues See more
Orthologs
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Genomic context

See Igf2 in Genome Data Viewer
Location:
7 F5; 7 87.99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142204505..142220566, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142650768..142666816, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene microRNA 675 Neighboring gene H19/Igf2 imprinting control region Neighboring gene H19, imprinted maternally expressed transcript Neighboring gene predicted gene, 33148 Neighboring gene H19 upstream conserved region 2 Neighboring gene H19 upstream conserved region 1 Neighboring gene STARR-seq mESC enhancer starr_20515 Neighboring gene microRNA 483 Neighboring gene insulin-like growth factor 2, opposite strand Neighboring gene insulin II Neighboring gene predicted gene, 39116 Neighboring gene STARR-positive B cell enhancer mm9_chr7:149922840-149923140

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin-like growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables receptor ligand activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic placenta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of vascular endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in spongiotrophoblast cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin-like growth factor II
Names
multiplication-stimulating polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122736.2NP_001116208.1  insulin-like growth factor II isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001116208.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC013548, BC058615, CN527329
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Related
    ENSMUSP00000101556.2, ENSMUST00000105936.8
    Conserved Domains (2) summary
    cd04368
    Location:2891
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
  2. NM_001122737.2NP_001116209.1  insulin-like growth factor II isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001116209.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC013548, BC058615
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Related
    ENSMUSP00000000033.6, ENSMUST00000000033.12
    Conserved Domains (2) summary
    cd04368
    Location:2891
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
  3. NM_001315488.1NP_001302417.1  insulin-like growth factor II isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC013548, CN666734
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Related
    ENSMUSP00000101555.2, ENSMUST00000105935.8
    Conserved Domains (2) summary
    cd04368
    Location:2891
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
  4. NM_001315489.1NP_001302418.1  insulin-like growth factor II isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate exon at its 5' terminus, lacks a portion of the 3' UTR and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC013548, BC053489
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Conserved Domains (2) summary
    cd04368
    Location:2891
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
  5. NM_010514.3NP_034644.2  insulin-like growth factor II isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
    Source sequence(s)
    AC013548, CF742200
    Consensus CDS
    CCDS22033.2
    UniProtKB/Swiss-Prot
    P09535
    Related
    ENSMUSP00000114076.2, ENSMUST00000121128.8
    Conserved Domains (2) summary
    cd04368
    Location:39102
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam08365
    Location:123177
    IGF2_C; Insulin-like growth factor II E-peptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142204505..142220566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152697.1XP_036008590.1  insulin-like growth factor II isoform X1

    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Conserved Domains (2) summary
    cd04368
    Location:2891
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
  2. XM_006508487.1XP_006508550.1  insulin-like growth factor II isoform X1

    See identical proteins and their annotated locations for XP_006508550.1

    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Conserved Domains (2) summary
    cd04368
    Location:2891
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
  3. XM_030242159.1XP_030098019.1  insulin-like growth factor II isoform X2

    Conserved Domains (1) summary
    cd04368
    Location:39102
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...