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Igf1r insulin-like growth factor I receptor [ Mus musculus (house mouse) ]

Gene ID: 16001, updated on 7-Apr-2024

Summary

Official Symbol
Igf1rprovided by MGI
Official Full Name
insulin-like growth factor I receptorprovided by MGI
Primary source
MGI:MGI:96433
See related
Ensembl:ENSMUSG00000005533 AllianceGenome:MGI:96433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hyft; CD221; IGF-1R; D930020L01; A330103N21Rik
Summary
Enables insulin-like growth factor binding activity. Involved in several processes, including adrenal gland development; positive regulation of cold-induced thermogenesis; and positive regulation of meiotic cell cycle. Acts upstream of or within several processes, including gland development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.6), kidney adult (RPKM 10.1) and 27 other tissues See more
Orthologs
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Genomic context

See Igf1r in Genome Data Viewer
Location:
7 C; 7 37.27 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (67601486..67883416)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (67952257..68233668)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833412C05 gene Neighboring gene predicted gene, 34350 Neighboring gene STARR-seq mESC enhancer starr_19103 Neighboring gene predicted gene, 39027 Neighboring gene STARR-seq mESC enhancer starr_19104 Neighboring gene STARR-positive B cell enhancer ABC_E9692 Neighboring gene predicted gene, 51487 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:75350823-75351006 Neighboring gene pyroglutamyl-peptidase I-like Neighboring gene STARR-positive B cell enhancer ABC_E8177 Neighboring gene STARR-seq mESC enhancer starr_19114 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:75434034-75434217 Neighboring gene family with sequence similarity 169, member B Neighboring gene aging liver Treg-expressed non-protein coding RNA Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:75468056-75468239 Neighboring gene predicted gene 16158

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor substrate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin-like growth factor receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables insulin-like growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adrenal gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin-like growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellum development ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in estrous cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within male sex determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholangiocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of meiotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in response to L-glutamate ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in transcytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
part_of alphav-beta3 integrin-IGF-1-IGF1R complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of insulin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor 1 receptor
Names
IGF-I receptor
line 186
NP_034643.2
XP_006540704.1
XP_006540705.1
XP_006540706.1
XP_006540707.1
XP_006540708.1
XP_017177475.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010513.3NP_034643.2  insulin-like growth factor 1 receptor precursor

    See identical proteins and their annotated locations for NP_034643.2

    Status: VALIDATED

    Source sequence(s)
    AC101879, AC158584
    Consensus CDS
    CCDS21355.1
    UniProtKB/TrEMBL
    E9QNX9
    Related
    ENSMUSP00000005671.9, ENSMUST00000005671.10
    Conserved Domains (7) summary
    cd05032
    Location:9931270
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:836925
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:230277
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:175330
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353467
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:10001265
    Pkinase_Tyr; Protein tyrosine kinase
    cl22855
    Location:207336
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    67601486..67883416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540642.5XP_006540705.1  insulin-like growth factor 1 receptor isoform X2

    Conserved Domains (4) summary
    cd05032
    Location:9931301
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:836925
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:175332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353466
    Recep_L_domain; Receptor L domain
  2. XM_006540641.5XP_006540704.1  insulin-like growth factor 1 receptor isoform X1

    Conserved Domains (4) summary
    cd05032
    Location:9941302
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:837926
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:175332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353466
    Recep_L_domain; Receptor L domain
  3. XM_006540643.5XP_006540706.1  insulin-like growth factor 1 receptor isoform X3

    Conserved Domains (4) summary
    cd05032
    Location:9941271
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:837926
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:175332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:353466
    Recep_L_domain; Receptor L domain
  4. XM_006540644.4XP_006540707.1  insulin-like growth factor 1 receptor isoform X4

    Conserved Domains (4) summary
    cd05032
    Location:7981106
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:641730
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:19136
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:157270
    Recep_L_domain; Receptor L domain
  5. XM_006540645.4XP_006540708.1  insulin-like growth factor 1 receptor isoform X5

    See identical proteins and their annotated locations for XP_006540708.1

    UniProtKB/TrEMBL
    Q3U1L4
    Conserved Domains (4) summary
    cd05032
    Location:7971074
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:640729
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:19136
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:157270
    Recep_L_domain; Receptor L domain
  6. XM_017321986.3XP_017177475.1  insulin-like growth factor 1 receptor isoform X6

    UniProtKB/TrEMBL
    Q3UVJ3
    Conserved Domains (4) summary
    cd05032
    Location:691999
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:534623
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:129
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:50163
    Recep_L_domain; Receptor L domain