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DEUP1 deuterosome assembly protein 1 [ Homo sapiens (human) ]

Gene ID: 159989, updated on 12-Oct-2019

Summary

Official Symbol
DEUP1provided by HGNC
Official Full Name
deuterosome assembly protein 1provided by HGNC
Primary source
HGNC:HGNC:26344
See related
Ensembl:ENSG00000165325 MIM:617148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC67
Expression
Restricted expression toward testis (RPKM 5.7) See more
Orthologs

Genomic context

See DEUP1 in Genome Data Viewer
Location:
11q21
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (93329079..93438470)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (93063156..93171636)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 31 Neighboring gene solute carrier family 36 member 4 Neighboring gene 6.8 kDa mitochondrial proteolipid-like Neighboring gene single-pass membrane protein with coiled-coil domains 4 Neighboring gene RNA, 7SL, cytoplasmic 223, pseudogene Neighboring gene signal recognition particle 14 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
multi-ciliated epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multi-ciliated epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
deuterosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deuterosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
deuterosome assembly protein 1
Names
coiled-coil domain containing 67
coiled-coil domain-containing protein 67
deuterosome protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181645.3NP_857596.2  deuterosome assembly protein 1

    See identical proteins and their annotated locations for NP_857596.2

    Status: VALIDATED

    Source sequence(s)
    AK058122, BC017929, BC031247, DB449834
    Consensus CDS
    CCDS44707.1
    UniProtKB/Swiss-Prot
    Q05D60
    Related
    ENSP00000298050.3, ENST00000298050.7
    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    93329079..93438470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542631.2XP_011540933.1  deuterosome assembly protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540933.1

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  2. XM_011542630.1XP_011540932.1  deuterosome assembly protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540932.1

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  3. XM_005273802.1XP_005273859.1  deuterosome assembly protein 1 isoform X3

    See identical proteins and their annotated locations for XP_005273859.1

    UniProtKB/Swiss-Prot
    Q05D60
    Related
    ENSP00000479457.1, ENST00000618031.4
    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  4. XM_011542629.2XP_011540931.1  deuterosome assembly protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540931.1

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  5. XM_011542635.2XP_011540937.1  deuterosome assembly protein 1 isoform X6

    Related
    ENSP00000433537.2, ENST00000531792.5
    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  6. XM_011542633.2XP_011540935.1  deuterosome assembly protein 1 isoform X5

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  7. XM_017017245.1XP_016872734.1  deuterosome assembly protein 1 isoform X2

  8. XM_011542632.3XP_011540934.1  deuterosome assembly protein 1 isoform X4

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  9. XM_011542637.2XP_011540939.1  deuterosome assembly protein 1 isoform X8

    Related
    ENSP00000434635.1, ENST00000532819.5
    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  10. XM_011542636.2XP_011540938.1  deuterosome assembly protein 1 isoform X7

    Conserved Domains (1) summary
    PRK03918
    Location:6155
    PRK03918; chromosome segregation protein; Provisional
  11. XM_011542638.2XP_011540940.1  deuterosome assembly protein 1 isoform X9

    UniProtKB/TrEMBL
    E9PLX9
    Related
    ENSP00000435079.1, ENST00000525646.1
    Conserved Domains (1) summary
    PRK03918
    Location:6155
    PRK03918; chromosome segregation protein; Provisional

RNA

  1. XR_947797.2 RNA Sequence

  2. XR_947800.2 RNA Sequence

  3. XR_947798.2 RNA Sequence

  4. XR_947799.2 RNA Sequence

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