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DEUP1 deuterosome assembly protein 1 [ Homo sapiens (human) ]

Gene ID: 159989, updated on 5-Aug-2022

Summary

Official Symbol
DEUP1provided by HGNC
Official Full Name
deuterosome assembly protein 1provided by HGNC
Primary source
HGNC:HGNC:26344
See related
Ensembl:ENSG00000165325 MIM:617148; AllianceGenome:HGNC:26344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC67
Summary
Enables identical protein binding activity. Predicted to be involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Predicted to be located in cytoplasm. Predicted to be integral component of membrane. Predicted to be active in centriole and deuterosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 5.7) See more
Orthologs
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Genomic context

See DEUP1 in Genome Data Viewer
Location:
11q21
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (93329998..93438470)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (93253554..93354907)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (93063908..93171636)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 member 4 Neighboring gene ATP synthase subunit ATP5MJ, mitochondrial-like Neighboring gene uncharacterized LOC124902734 Neighboring gene single-pass membrane protein with coiled-coil domains 4 Neighboring gene SRP14 pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 223, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in multi-ciliated epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in deuterosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in deuterosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
deuterosome assembly protein 1
Names
coiled-coil domain containing 67
coiled-coil domain-containing protein 67
deuterosome protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181645.4NP_857596.2  deuterosome assembly protein 1

    See identical proteins and their annotated locations for NP_857596.2

    Status: VALIDATED

    Source sequence(s)
    AK058122, BC017929, BC031247
    Consensus CDS
    CCDS44707.1
    UniProtKB/Swiss-Prot
    Q05D60, Q96LL7
    Related
    ENSP00000298050.3, ENST00000298050.9
    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    93329998..93438470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542631.3XP_011540933.1  deuterosome assembly protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540933.1

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  2. XM_047426455.1XP_047282411.1  deuterosome assembly protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q96LL7
  3. XM_011542630.2XP_011540932.1  deuterosome assembly protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540932.1

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  4. XM_005273802.2XP_005273859.1  deuterosome assembly protein 1 isoform X2

    See identical proteins and their annotated locations for XP_005273859.1

    UniProtKB/Swiss-Prot
    Q05D60, Q96LL7
    Related
    ENSP00000479457.1, ENST00000618031.4
    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  5. XM_011542633.3XP_011540935.1  deuterosome assembly protein 1 isoform X6

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  6. XM_011542629.3XP_011540931.1  deuterosome assembly protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540931.1

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  7. XM_011542635.3XP_011540937.1  deuterosome assembly protein 1 isoform X7

    Related
    ENSP00000433537.2, ENST00000531792.5
    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  8. XM_011542632.4XP_011540934.1  deuterosome assembly protein 1 isoform X3

    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  9. XM_047426456.1XP_047282412.1  deuterosome assembly protein 1 isoform X4

  10. XM_047426457.1XP_047282413.1  deuterosome assembly protein 1 isoform X5

  11. XM_011542637.3XP_011540939.1  deuterosome assembly protein 1 isoform X9

    Related
    ENSP00000434635.1, ENST00000532819.5
    Conserved Domains (1) summary
    pfam17045
    Location:11280
    CEP63; Centrosomal protein of 63 kDa
  12. XM_011542638.3XP_011540940.1  deuterosome assembly protein 1 isoform X10

    UniProtKB/TrEMBL
    E9PLX9
    Related
    ENSP00000435079.1, ENST00000525646.1
    Conserved Domains (1) summary
    PRK03918
    Location:6155
    PRK03918; chromosome segregation protein; Provisional
  13. XM_011542636.3XP_011540938.1  deuterosome assembly protein 1 isoform X8

    Conserved Domains (1) summary
    PRK03918
    Location:6155
    PRK03918; chromosome segregation protein; Provisional

RNA

  1. XR_007062456.1 RNA Sequence

  2. XR_947798.3 RNA Sequence

  3. XR_007062457.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    93253554..93354907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)