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Cd79b CD79B antigen [ Mus musculus (house mouse) ]

Gene ID: 15985, updated on 10-Oct-2019

Summary

Official Symbol
Cd79bprovided by MGI
Official Full Name
CD79B antigenprovided by MGI
Primary source
MGI:MGI:96431
See related
Ensembl:ENSMUSG00000040592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B29; Igb; Igbeta; Ig-beta
Summary
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2015]
Expression
Biased expression in spleen adult (RPKM 246.8), mammary gland adult (RPKM 54.7) and 2 other tissues See more
Orthologs

Genomic context

See Cd79b in Genome Data Viewer
Location:
11 E1; 11 68.89 cM
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106311341..106314562, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106172655..106175843, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene testicular cell adhesion molecule 1 Neighboring gene growth hormone Neighboring gene sodium channel, voltage-gated, type IV, alpha Neighboring gene uncharacterized LOC108167929

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
B cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
B-cell antigen receptor complex-associated protein beta chain
Names
B-cell-specific glycoprotein B29
immunoglobulin-associated B29 protein
immunoglobulin-associated beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313939.1NP_001300868.1  B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK143573, BE633998, BU699329
    UniProtKB/Swiss-Prot
    P15530
    Conserved Domains (3) summary
    smart00077
    Location:175194
    ITAM; Immunoreceptor tyrosine-based activation motif
    smart00410
    Location:44124
    IG_like; Immunoglobulin like
    cl11960
    Location:44125
    Ig; Immunoglobulin domain
  2. NM_008339.3NP_032365.1  B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_032365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK143573, BE633998, BU695347
    Consensus CDS
    CCDS48960.1
    UniProtKB/Swiss-Prot
    P15530
    Related
    ENSMUSP00000129029.1, ENSMUST00000167143.1
    Conserved Domains (3) summary
    smart00077
    Location:192211
    ITAM; Immunoreceptor tyrosine-based activation motif
    smart00410
    Location:61141
    IG_like; Immunoglobulin like
    cl11960
    Location:61142
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    106311341..106314562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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