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Ifngr2 interferon gamma receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 15980, updated on 8-Feb-2024

Summary

Official Symbol
Ifngr2provided by MGI
Official Full Name
interferon gamma receptor 2provided by MGI
Primary source
MGI:MGI:107654
See related
Ensembl:ENSMUSG00000022965 AllianceGenome:MGI:107654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifgt; Ifgr2
Summary
Predicted to enable cytokine receptor activity. Acts upstream of or within defense response to virus. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 28. Orthologous to human IFNGR2 (interferon gamma receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 148.1), small intestine adult (RPKM 81.1) and 22 other tissues See more
Orthologs
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Genomic context

See Ifngr2 in Genome Data Viewer
Location:
16 C3.3; 16 53.07 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91343947..91360895)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91547059..91564007)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene microRNA 6367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91541844-91542045 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91545797-91546039 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91546296-91546449 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41480 Neighboring gene transmembrane protein 50B Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91588013-91588235 Neighboring gene STARR-positive B cell enhancer ABC_E3173 Neighboring gene STARR-positive B cell enhancer mm9_chr16:91619128-91619428 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type II interferon receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in type III interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon gamma receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008338.4NP_032364.1  interferon gamma receptor 2 precursor

    See identical proteins and their annotated locations for NP_032364.1

    Status: VALIDATED

    Source sequence(s)
    AC159199
    Consensus CDS
    CCDS28327.1
    UniProtKB/TrEMBL
    Q3UVK9, Q63953
    Related
    ENSMUSP00000023687.8, ENSMUST00000023687.9
    Conserved Domains (2) summary
    pfam01108
    Location:24121
    Tissue_fac; Tissue factor
    cl21522
    Location:134233
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91343947..91360895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)