U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ifngr1 interferon gamma receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 15979, updated on 26-Jun-2024

Summary

Official Symbol
Ifngr1provided by MGI
Official Full Name
interferon gamma receptor 1provided by MGI
Primary source
MGI:MGI:107655
See related
Ensembl:ENSMUSG00000020009 AllianceGenome:MGI:107655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
Summary
Predicted to enable cytokine receptor activity. Involved in several processes, including astrocyte activation; negative regulation of amyloid-beta clearance; and positive regulation of macromolecule metabolic process. Acts upstream of or within defense response to virus. Predicted to be located in several cellular components, including dendrite; endoplasmic reticulum; and postsynaptic density. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; cerebral cortex; cranium; female reproductive system; and liver. Used to study osteoporosis. Human ortholog(s) of this gene implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Orthologous to human IFNGR1 (interferon gamma receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 45.9), colon adult (RPKM 37.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ifngr1 in Genome Data Viewer
Location:
10 A3; 10 8.49 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (19467697..19485977)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (19591949..19610229)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19093659-19093906 Neighboring gene oligodendrocyte transcription factor 3 Neighboring gene STARR-seq mESC enhancer starr_25934 Neighboring gene STARR-seq mESC enhancer starr_25935 Neighboring gene STARR-seq mESC enhancer starr_25937 Neighboring gene predicted gene, 33104 Neighboring gene STARR-positive B cell enhancer mm9_chr10:19238623-19238923 Neighboring gene STARR-seq mESC enhancer starr_25938 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19303894-19304196 Neighboring gene STARR-positive B cell enhancer ABC_E2317 Neighboring gene STARR-seq mESC enhancer starr_25939 Neighboring gene interleukin 22 receptor, alpha 2 Neighboring gene predicted gene, 33332 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19411574-19411868 Neighboring gene interleukin 20 receptor, alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type II interferon receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon gamma receptor 1
Names
IFN-gamma receptor 1
IFN-gamma-R-alpha
IFN-gamma-R1
INF-g receptor
interferon gamma receptor alpha-chain

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010511.3NP_034641.1  interferon gamma receptor 1 precursor

    See identical proteins and their annotated locations for NP_034641.1

    Status: VALIDATED

    Source sequence(s)
    AK151079, BU700524, BY754033
    Consensus CDS
    CCDS35856.1
    UniProtKB/Swiss-Prot
    P15261, Q91Y85
    UniProtKB/TrEMBL
    Q3TW49, Q3U8T2, Q540M5
    Related
    ENSMUSP00000020188.7, ENSMUST00000020188.13
    Conserved Domains (2) summary
    pfam01108
    Location:33119
    Tissue_fac; Tissue factor
    pfam07140
    Location:168324
    IFNGR1; Interferon gamma receptor (IFNGR1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    19467697..19485977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)