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Ifng interferon gamma [ Mus musculus (house mouse) ]

Gene ID: 15978, updated on 5-Dec-2021

Summary

Official Symbol
Ifngprovided by MGI
Official Full Name
interferon gammaprovided by MGI
Primary source
MGI:MGI:107656
See related
Ensembl:ENSMUSG00000055170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifg; If2f; IFN-g
Summary
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Ifng in Genome Data Viewer
Location:
10 D2; 10 66.75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (118276951..118281799)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (118441046..118445894)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (117878103..117882948)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9048 Neighboring gene predicted gene 9049 Neighboring gene Ifng antisense RNA 1 Neighboring gene predicted gene, 33337

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables interferon-gamma receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-18 IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to virus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within humoral immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interferon-gamma-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interferon-gamma-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid-beta clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of amyloid-beta clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myelination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation by host of viral process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MHC class II biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MHC class II biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of NMDA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of amyloid-beta formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of amyloid-beta formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular respiration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of core promoter binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fructose 1,6-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-23 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of iron ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of killing of cells of other organism ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of nitrogen compound metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of nitrogen compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of signaling receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vitamin D biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in sensory perception of mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon gamma
Names
IFN-gamma
gamma interferon
interferon 2f

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008337.4NP_032363.1  interferon gamma precursor

    See identical proteins and their annotated locations for NP_032363.1

    Status: REVIEWED

    Source sequence(s)
    AC153498
    Consensus CDS
    CCDS24200.1
    UniProtKB/Swiss-Prot
    P01580
    Related
    ENSMUSP00000063800.4, ENSMUST00000068592.5
    Conserved Domains (1) summary
    pfam00714
    Location:14150
    IFN-gamma; Interferon gamma

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    118276951..118281799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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