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Ifnb1 interferon beta 1, fibroblast [ Mus musculus (house mouse) ]

Gene ID: 15977, updated on 23-Nov-2021

Summary

Official Symbol
Ifnb1provided by MGI
Official Full Name
interferon beta 1, fibroblastprovided by MGI
Primary source
MGI:MGI:107657
See related
Ensembl:ENSMUSG00000048806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifb; IFNB; If1da1; IFN-beta
Orthologs
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Genomic context

See Ifnb1 in Genome Data Viewer
Location:
4 C4; 4 41.91 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (88440262..88441031, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (88522025..88522794, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (88167929..88168698, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene focadhesin Neighboring gene microRNA 491 Neighboring gene 3-hydroxyacyl-CoA dehydratase 4 Neighboring gene interferon alpha 15 Neighboring gene interferon alpha 14

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloramphenicol O-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables type I interferon receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type I interferon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to dsRNA IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within humoral immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in natural killer cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in type I interferon signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type I interferon signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon beta
Names
interferon 1da1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010510.1NP_034640.1  interferon beta precursor

    See identical proteins and their annotated locations for NP_034640.1

    Status: VALIDATED

    Source sequence(s)
    K00020
    Consensus CDS
    CCDS18318.1
    UniProtKB/Swiss-Prot
    P01575
    UniProtKB/TrEMBL
    Q0VE17
    Related
    ENSMUSP00000056720.4, ENSMUST00000055671.5
    Conserved Domains (1) summary
    cd00095
    Location:27173
    IFab; Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    88440262..88441031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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