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Ifit3 interferon-induced protein with tetratricopeptide repeats 3 [ Mus musculus (house mouse) ]

Gene ID: 15959, updated on 30-Apr-2024

Summary

Official Symbol
Ifit3provided by MGI
Official Full Name
interferon-induced protein with tetratricopeptide repeats 3provided by MGI
Primary source
MGI:MGI:1101055
See related
Ensembl:ENSMUSG00000074896 AllianceGenome:MGI:1101055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P49; Ifi49
Summary
Predicted to enable RNA binding activity and identical protein binding activity. Acts upstream of or within cellular response to interferon-beta; response to bacterium; and response to stilbenoid. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Is expressed in alimentary system; eye; face; and nervous system. Orthologous to human IFIT3 (interferon induced protein with tetratricopeptide repeats 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 9.6), liver E18 (RPKM 8.0) and 17 other tissues See more
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Genomic context

See Ifit3 in Genome Data Viewer
Location:
19 C1; 19 29.74 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34560519..34566382)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34583119..34588982)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4275 Neighboring gene predicted gene, 31417 Neighboring gene interferon-induced protein with tetratricopeptide repeats 2 Neighboring gene STARR-positive B cell enhancer ABC_E11027 Neighboring gene STARR-positive B cell enhancer ABC_E11028 Neighboring gene interferon induced protein with tetratricpeptide repeats 1B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5698 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3B Neighboring gene interferon induced protein with tetratricopeptide repeats 1B like 2 Neighboring gene calponin2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107331

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon-induced protein with tetratricopeptide repeats 3
Names
GARG-49
IFIT-3
IRG2
glucocorticoid-attenuated response gene 49 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010501.2NP_034631.1  interferon-induced protein with tetratricopeptide repeats 3

    See identical proteins and their annotated locations for NP_034631.1

    Status: VALIDATED

    Source sequence(s)
    AK153226
    Consensus CDS
    CCDS29762.1
    UniProtKB/Swiss-Prot
    Q64345, Q99L62
    UniProtKB/TrEMBL
    Q4FJY6, Q5FW82
    Related
    ENSMUSP00000099889.4, ENSMUST00000102825.4
    Conserved Domains (3) summary
    COG5010
    Location:136272
    TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]
    sd00006
    Location:136164
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:48126
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34560519..34566382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247153.2XP_011245455.1  interferon-induced protein with tetratricopeptide repeats 3 isoform X2

    UniProtKB/TrEMBL
    Q4FJY6
    Conserved Domains (3) summary
    TIGR02917
    Location:81325
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:161189
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:76151
    TPR_12; Tetratricopeptide repeat
  2. XM_011247151.3XP_011245453.1  interferon-induced protein with tetratricopeptide repeats 3 isoform X1

    See identical proteins and their annotated locations for XP_011245453.1

    UniProtKB/TrEMBL
    Q4FJY6
    Conserved Domains (3) summary
    TIGR02917
    Location:87331
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:167195
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:82157
    TPR_12; Tetratricopeptide repeat
  3. XM_036161448.1XP_036017341.1  interferon-induced protein with tetratricopeptide repeats 3 isoform X3

    UniProtKB/TrEMBL
    Q4FJY6
    Conserved Domains (3) summary
    TIGR02917
    Location:64308
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:144172
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:59134
    TPR_12; Tetratricopeptide repeat