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Ier2 immediate early response 2 [ Mus musculus (house mouse) ]

Gene ID: 15936, updated on 30-Apr-2024

Summary

Official Symbol
Ier2provided by MGI
Official Full Name
immediate early response 2provided by MGI
Primary source
MGI:MGI:104815
See related
Ensembl:ENSMUSG00000053560 AllianceGenome:MGI:104815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ch1; Pip92
Summary
Predicted to be involved in several processes, including neuron differentiation; positive regulation of transcription by RNA polymerase II; and response to fibroblast growth factor. Located in cytoplasm. Is expressed in several structures, including ear; forelimb bud; submandibular gland primordium; tooth; and vibrissa. Orthologous to human IER2 (immediate early response 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Ier2 in Genome Data Viewer
Location:
8 C3; 8 41.02 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85387960..85389481, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84661331..84662852, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Neighboring gene STARR-seq mESC enhancer starr_22132 Neighboring gene STARR-seq mESC enhancer starr_22133 Neighboring gene predicted gene, 39212 Neighboring gene STARR-seq mESC enhancer starr_22134 Neighboring gene STARR-positive B cell enhancer ABC_E5025 Neighboring gene STARR-positive B cell enhancer ABC_E883 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87188874-87189057 Neighboring gene predicted gene, 39211 Neighboring gene predicted gene, 26664 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing Neighboring gene tRNA methyltransferase 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
immediate early response gene 2 protein
Names
CHX1
T-lymphocyte-activated protein
cycloheximide-induced gene protein
growth factor-inducible immediate early protein
proline-rich-induced protein 92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010499.4NP_034629.3  immediate early response gene 2 protein

    See identical proteins and their annotated locations for NP_034629.3

    Status: VALIDATED

    Source sequence(s)
    AK144601, BP770574, BU604538
    Consensus CDS
    CCDS22474.1
    UniProtKB/Swiss-Prot
    P17950, Q3TD12, Q64251, Q8BME8, Q99M25
    UniProtKB/TrEMBL
    Q3T9S0
    Related
    ENSMUSP00000060275.5, ENSMUST00000060427.6
    Conserved Domains (1) summary
    pfam05760
    Location:1100
    IER; Immediate early response protein (IER)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85387960..85389481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)