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Ido1 indoleamine 2,3-dioxygenase 1 [ Mus musculus (house mouse) ]

Gene ID: 15930, updated on 5-Aug-2018
Official Symbol
Ido1provided by MGI
Official Full Name
indoleamine 2,3-dioxygenase 1provided by MGI
Primary source
MGI:MGI:96416
See related
Ensembl:ENSMUSG00000031551 Vega:OTTMUSG00000020648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ido; Indo
Expression
Biased expression in genital fat pad adult (RPKM 37.1), mammary gland adult (RPKM 7.7) and 2 other tissues See more
Orthologs
See Ido1 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (24584133..24596952, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (25694613..25707481, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9130214F15 gene Neighboring gene indoleamine 2,3-dioxygenase 2 Neighboring gene a disintegrin and metallopeptidase domain 18 Neighboring gene a disintegrin and metallopeptidase domain 3 (cyritestin)

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
amino acid binding ISO
Inferred from Sequence Orthology
more info
 
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
indoleamine 2,3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxygen binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tryptophan 2,3-dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
tryptophan 2,3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response TAS
Traceable Author Statement
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
kynurenic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chronic inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
swimming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
 
tryptophan catabolic process to kynurenine IDA
Inferred from Direct Assay
more info
PubMed 
tryptophan catabolic process to kynurenine ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
smooth muscle contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 
stereocilium bundle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
indoleamine 2,3-dioxygenase 1
Names
IDO-1
indole 2,3-dioxygenase
indoleamine-pyrrole 2,3 dioxygenase
NP_001280619.1
NP_032350.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293690.1NP_001280619.1  indoleamine 2,3-dioxygenase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK033783, AV381637, M69109
    Consensus CDS
    CCDS80866.1
    UniProtKB/Swiss-Prot
    P28776
    UniProtKB/TrEMBL
    D3YXV1
    Related
    ENSMUSP00000106295.1, OTTMUSP00000022552, ENSMUST00000110667.7, OTTMUST00000048916
    Conserved Domains (1) summary
    pfam01231
    Location:1311
    IDO; Indoleamine 2,3-dioxygenase
  2. NM_008324.2NP_032350.1  indoleamine 2,3-dioxygenase 1 isoform 1

    See identical proteins and their annotated locations for NP_032350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AV381637, M69109
    Consensus CDS
    CCDS40299.1
    UniProtKB/Swiss-Prot
    P28776
    Related
    ENSMUSP00000033956.6, OTTMUSP00000022551, ENSMUST00000033956.6, OTTMUST00000048915
    Conserved Domains (1) summary
    pfam01231
    Location:16402
    IDO; Indoleamine 2,3-dioxygenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    24584133..24596952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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