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Ido1 indoleamine 2,3-dioxygenase 1 [ Mus musculus (house mouse) ]

Gene ID: 15930, updated on 8-Feb-2024

Summary

Official Symbol
Ido1provided by MGI
Official Full Name
indoleamine 2,3-dioxygenase 1provided by MGI
Primary source
MGI:MGI:96416
See related
Ensembl:ENSMUSG00000031551 AllianceGenome:MGI:96416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ido; Indo
Summary
Enables tryptophan 2,3-dioxygenase activity. Acts upstream of or within several processes, including carboxylic acid metabolic process; regulation of apoptotic process; and regulation of cytokine production. Located in smooth muscle contractile fiber and stereocilium bundle. Is expressed in cerebral cortex; corpus striatum; embryo; extraembryonic component; and hippocampus. Used to study pre-eclampsia. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 37.1), mammary gland adult (RPKM 7.7) and 2 other tissues See more
Orthologs
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Genomic context

See Ido1 in Genome Data Viewer
Location:
8 A2; 8 12.76 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25074148..25086987, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (24584133..24596952, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9130214F15 gene Neighboring gene STARR-seq mESC enhancer starr_20944 Neighboring gene indoleamine 2,3-dioxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_20946 Neighboring gene STARR-seq mESC enhancer starr_20947 Neighboring gene predicted gene, 51565 Neighboring gene a disintegrin and metallopeptidase domain 18 Neighboring gene predicted gene, 51566 Neighboring gene predicted gene, 26208 Neighboring gene ADAM metallopeptidase domain 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables indoleamine 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables indoleamine 2,3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tryptophan 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tryptophan 2,3-dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kynurenic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of chronic inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within swimming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within tryptophan catabolic process to kynurenine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tryptophan catabolic process to kynurenine ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in smooth muscle contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in stereocilium bundle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
indoleamine 2,3-dioxygenase 1
Names
IDO-1
indole 2,3-dioxygenase
indoleamine-pyrrole 2,3 dioxygenase
NP_001280619.1
NP_032350.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293690.2NP_001280619.1  indoleamine 2,3-dioxygenase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114602
    Consensus CDS
    CCDS80866.1
    UniProtKB/TrEMBL
    D3YXV1
    Related
    ENSMUSP00000106295.2, ENSMUST00000110667.8
    Conserved Domains (1) summary
    pfam01231
    Location:1311
    IDO; Indoleamine 2,3-dioxygenase
  2. NM_008324.3NP_032350.1  indoleamine 2,3-dioxygenase 1 isoform 1

    See identical proteins and their annotated locations for NP_032350.1

    Status: VALIDATED

    Source sequence(s)
    AC114602
    Consensus CDS
    CCDS40299.1
    UniProtKB/Swiss-Prot
    P28776
    Related
    ENSMUSP00000033956.7, ENSMUST00000033956.7
    Conserved Domains (1) summary
    pfam01231
    Location:16402
    IDO; Indoleamine 2,3-dioxygenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    25074148..25086987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)