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Id1 inhibitor of DNA binding 1, HLH protein [ Mus musculus (house mouse) ]

Gene ID: 15901, updated on 26-Sep-2022

Summary

Official Symbol
Id1provided by MGI
Official Full Name
inhibitor of DNA binding 1, HLH proteinprovided by MGI
Primary source
MGI:MGI:96396
See related
Ensembl:ENSMUSG00000042745 AllianceGenome:MGI:96396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Idb1; bHLHb24; D2Wsu140e
Summary
Enables protein self-association and transcription regulator inhibitor activity. Involved in negative regulation of cold-induced thermogenesis; negative regulation of transcription, DNA-templated; and positive regulation of gene expression. Acts upstream of or within several processes, including endothelial cell morphogenesis; lung development; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ID1 (inhibitor of DNA binding 1, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 416.7), colon adult (RPKM 399.7) and 22 other tissues See more
Orthologs
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Genomic context

See Id1 in Genome Data Viewer
Location:
2 H1; 2 75.41 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152578171..152579330)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152736251..152737410)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700030C14 gene Neighboring gene histocompatibility 13 Neighboring gene malignant T cell amplified sequence 2 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene, 32057 Neighboring gene cytochrome c oxidase subunit 4I2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within collagen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endothelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein destabilization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vasculature development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-binding protein inhibitor ID-1
Names
inhibitor of differentiation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355113.1NP_001342042.1  DNA-binding protein inhibitor ID-1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses a splice site in the 3' region, compared to variant 3. This results in a shorter protein (isoform 1), compared to isoform 3.
    Source sequence(s)
    AL731857, AV588021
    Conserved Domains (1) summary
    cd00083
    Location:61102
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. NM_001369018.1NP_001355947.1  DNA-binding protein inhibitor ID-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AL731857
    Consensus CDS
    CCDS89567.1
    UniProtKB/TrEMBL
    A2AHY3
    Related
    ENSMUSP00000105449.2, ENSMUST00000109824.2
    Conserved Domains (1) summary
    cd00083
    Location:61102
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  3. NM_010495.3NP_034625.1  DNA-binding protein inhibitor ID-1 isoform 2

    See identical proteins and their annotated locations for NP_034625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a splice site in the 3' region, compared to variant 3. This results in a shorter protein (isoform 2), compared to isoform 3.
    Source sequence(s)
    AL731857
    Consensus CDS
    CCDS16897.1
    UniProtKB/TrEMBL
    A0A8C6MNS5, Q6GTZ3
    Related
    ENSMUSP00000092019.5, ENSMUST00000038368.9
    Conserved Domains (1) summary
    cd00083
    Location:61102
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152578171..152579330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)