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Icam1 intercellular adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 15894, updated on 22-Aug-2021

Summary

Official Symbol
Icam1provided by MGI
Official Full Name
intercellular adhesion molecule 1provided by MGI
Primary source
MGI:MGI:96392
See related
Ensembl:ENSMUSG00000037405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAL; CD54; Icam; Ly-4; Ly-47; Icam-1; MALA-2
Summary
This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1. It participates in the innate immune response. [provided by RefSeq, Aug 2016]
Expression
Biased expression in lung adult (RPKM 157.0), spleen adult (RPKM 29.7) and 6 other tissues See more
Orthologs
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Genomic context

See Icam1 in Genome Data Viewer
Location:
9 A3; 9 7.69 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20927236..20940110)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21015940..21028814)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (20820404..20833241)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene intercellular adhesion molecule 4, Landsteiner-Wiener blood group Neighboring gene microRNA 1900 Neighboring gene intercellular adhesion molecule 5, telencephalin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC6195

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in adhesion of symbiont to host ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in establishment of Sertoli cell barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated virion attachment to host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ruffle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
intercellular adhesion molecule 1
Names
myD10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010493.3NP_034623.1  intercellular adhesion molecule 1 precursor

    See identical proteins and their annotated locations for NP_034623.1

    Status: REVIEWED

    Source sequence(s)
    AK151681, AW491621, BY777078
    Consensus CDS
    CCDS22889.1
    UniProtKB/Swiss-Prot
    P13597
    UniProtKB/TrEMBL
    Q3U8M7
    Related
    ENSMUSP00000083587.5, ENSMUST00000086399.6
    Conserved Domains (4) summary
    cd05755
    Location:112206
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    smart00410
    Location:408478
    IG_like; Immunoglobulin like
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:313391
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20927236..20940110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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