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USP51 ubiquitin specific peptidase 51 [ Homo sapiens (human) ]

Gene ID: 158880, updated on 23-Nov-2021

Summary

Official Symbol
USP51provided by HGNC
Official Full Name
ubiquitin specific peptidase 51provided by HGNC
Primary source
HGNC:HGNC:23086
See related
Ensembl:ENSG00000247746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in thyroid (RPKM 4.9), ovary (RPKM 3.8) and 23 other tissues See more
Orthologs
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Genomic context

See USP51 in Genome Data Viewer
Location:
Xp11.21
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (55484524..55489875, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55511049..55516281, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene microRNA 4536-1 Neighboring gene microRNA 4536-2 Neighboring gene MAGE family member H1 Neighboring gene uncharacterized LOC101928692 Neighboring gene MAGE family member E1 pseudogene Neighboring gene PSMA5 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of smoking behaviours among Bangladeshi adults.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 51
Names
deubiquitinating enzyme 51
ubiquitin thioesterase 51
ubiquitin thiolesterase 51
ubiquitin-specific-processing protease 51
NP_958443.1
XP_016884789.1
XP_016884790.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021371.1 RefSeqGene

    Range
    5001..9583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_201286.4NP_958443.1  ubiquitin carboxyl-terminal hydrolase 51

    See identical proteins and their annotated locations for NP_958443.1

    Status: VALIDATED

    Source sequence(s)
    AL590410
    Consensus CDS
    CCDS14370.1
    UniProtKB/Swiss-Prot
    Q70EK9
    Related
    ENSP00000423333.2, ENST00000500968.4
    Conserved Domains (3) summary
    cd02660
    Location:363704
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:362703
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:236296
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    55484524..55489875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029301.1XP_016884790.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q70EK9
    Conserved Domains (3) summary
    cd02660
    Location:363704
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:362703
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:236296
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  2. XM_017029300.1XP_016884789.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q70EK9
    Conserved Domains (3) summary
    cd02660
    Location:363704
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:362703
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:236296
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
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