U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

USP51 ubiquitin specific peptidase 51 [ Homo sapiens (human) ]

Gene ID: 158880, updated on 17-Sep-2022

Summary

Official Symbol
USP51provided by HGNC
Official Full Name
ubiquitin specific peptidase 51provided by HGNC
Primary source
HGNC:HGNC:23086
See related
Ensembl:ENSG00000247746 AllianceGenome:HGNC:23086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables chromatin binding activity; histone binding activity; and thiol-dependent deubiquitinase. Involved in histone deubiquitination; regulation of cell cycle process; and regulation of double-strand break repair. Predicted to be located in chromosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thyroid (RPKM 4.9), ovary (RPKM 3.8) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See USP51 in Genome Data Viewer
Location:
Xp11.21
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55484616..55489848, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (54776519..54781751)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55511049..55516281, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene microRNA 4536-1 Neighboring gene microRNA 4536-2 Neighboring gene MAGE family member H1 Neighboring gene uncharacterized LOC101928692 Neighboring gene MAGE family member E1 pseudogene Neighboring gene PSMA5 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 51
Names
deubiquitinating enzyme 51
ubiquitin thioesterase 51
ubiquitin thiolesterase 51
ubiquitin-specific-processing protease 51
NP_958443.1
XP_016884789.1
XP_016884790.1
XP_047297826.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021371.1 RefSeqGene

    Range
    4351..9583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_201286.4NP_958443.1  ubiquitin carboxyl-terminal hydrolase 51

    See identical proteins and their annotated locations for NP_958443.1

    Status: VALIDATED

    Source sequence(s)
    AL590410
    Consensus CDS
    CCDS14370.1
    UniProtKB/Swiss-Prot
    Q70EK9, Q8IWJ8
    Related
    ENSP00000423333.2, ENST00000500968.4
    Conserved Domains (3) summary
    cd02660
    Location:363704
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:362703
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:236296
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    55484616..55489848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029301.2XP_016884790.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q70EK9, Q8IWJ8
    Conserved Domains (3) summary
    cd02660
    Location:363704
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:362703
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:236296
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  2. XM_017029300.2XP_016884789.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q70EK9, Q8IWJ8
    Conserved Domains (3) summary
    cd02660
    Location:363704
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:362703
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:236296
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  3. XM_047441870.1XP_047297826.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

    UniProtKB/Swiss-Prot
    Q8IWJ8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    54776519..54781751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)