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ZDHHC15 zinc finger DHHC-type palmitoyltransferase 15 [ Homo sapiens (human) ]

Gene ID: 158866, updated on 23-Nov-2021

Summary

Official Symbol
ZDHHC15provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 15provided by HGNC
Primary source
HGNC:HGNC:20342
See related
Ensembl:ENSG00000102383 MIM:300576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRX91; DHHC15
Summary
The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in brain (RPKM 1.4), thyroid (RPKM 0.9) and 21 other tissues See more
Orthologs
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Genomic context

See ZDHHC15 in Genome Data Viewer
Location:
Xq13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (75368427..75523259, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (74588262..74742872, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uracil phosphoribosyltransferase homolog Neighboring gene RNA, U6 small nuclear 562, pseudogene Neighboring gene TERF1 pseudogene 7 Neighboring gene ribosomal protein L21 pseudogene 134 Neighboring gene uncharacterized LOC107985664 Neighboring gene PEST containing nuclear protein pseudogene 4 Neighboring gene BRAF pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-07-25)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-07-25)

ClinGen Genome Curation Page

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31812, MGC119974, MGC119975, MGC119976

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-cysteine S-stearoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to postsynapse ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC15
Names
DHHC-15
acyltransferase ZDHHC15
zinc finger DHHC domain-containing protein 15
zinc finger DHHC-type containing 15
zinc finger, DHHC domain containing 15
NP_001139728.1
NP_001139729.1
NP_659406.1
XP_006724687.1
XP_016884785.1
XP_016884786.1
XP_016884787.1
XP_024308110.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012974.1 RefSeqGene

    Range
    5466..160076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146256.2NP_001139728.1  palmitoyltransferase ZDHHC15 isoform 2

    See identical proteins and their annotated locations for NP_001139728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is lacking an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing a 9 aa segment compared to isoform 1.
    Source sequence(s)
    AK056374, AK122885, AK123754, AK128587, AL137013, BQ028106
    Consensus CDS
    CCDS55454.1
    UniProtKB/Swiss-Prot
    Q96MV8
    UniProtKB/TrEMBL
    B3KY34
    Related
    ENSP00000445420.1, ENST00000541184.1
    Conserved Domains (1) summary
    cl19890
    Location:117299
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_001146257.2NP_001139729.1  palmitoyltransferase ZDHHC15 isoform 3

    See identical proteins and their annotated locations for NP_001139729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is lacking an in-frame coding exon and differs at the 3' end compared to variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC020717, AY358786
    UniProtKB/Swiss-Prot
    Q96MV8
  3. NM_144969.3NP_659406.1  palmitoyltransferase ZDHHC15 isoform 1

    See identical proteins and their annotated locations for NP_659406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK056374, AK122885, AK123754, AK128587, AL137013, BQ028106
    Consensus CDS
    CCDS14430.1
    UniProtKB/Swiss-Prot
    Q96MV8
    UniProtKB/TrEMBL
    B3KY34
    Related
    ENSP00000362465.3, ENST00000373367.8
    Conserved Domains (1) summary
    cl19890
    Location:126308
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    75368427..75523259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452342.1XP_024308110.1  palmitoyltransferase ZDHHC15 isoform X3

    Conserved Domains (1) summary
    cl19890
    Location:18200
    zf-DHHC; DHHC palmitoyltransferase
  2. XM_017029297.1XP_016884786.1  palmitoyltransferase ZDHHC15 isoform X4

  3. XM_006724624.4XP_006724687.1  palmitoyltransferase ZDHHC15 isoform X1

    See identical proteins and their annotated locations for XP_006724687.1

    UniProtKB/Swiss-Prot
    Q96MV8
    Conserved Domains (1) summary
    cl19890
    Location:126308
    zf-DHHC; DHHC palmitoyltransferase
  4. XM_017029296.2XP_016884785.1  palmitoyltransferase ZDHHC15 isoform X2

  5. XM_017029298.1XP_016884787.1  palmitoyltransferase ZDHHC15 isoform X5

RNA

  1. XR_002958764.1 RNA Sequence

  2. XR_001755658.2 RNA Sequence

  3. XR_938393.2 RNA Sequence

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