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MOSPD2 motile sperm domain containing 2 [ Homo sapiens (human) ]

Gene ID: 158747, updated on 22-Sep-2022

Summary

Official Symbol
MOSPD2provided by HGNC
Official Full Name
motile sperm domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28381
See related
Ensembl:ENSG00000130150 MIM:301086; AllianceGenome:HGNC:28381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in positive regulation of monocyte chemotaxis and positive regulation of neutrophil chemotaxis. Located in endoplasmic reticulum and endoplasmic reticulum-endosome membrane contact site. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 8.4), brain (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

See MOSPD2 in Genome Data Viewer
Location:
Xp22.2
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (14873421..14922327)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (14453939..14503195)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (14891543..14940449)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene glycine receptor alpha 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:14691306-14692505 Neighboring gene FA complementation group B Neighboring gene nucleophosmin 1 pseudogene 9 Neighboring gene TPT1 pseudogene 14 Neighboring gene ribosomal protein L35a pseudogene 37

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26706, DKFZp686C1553

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
motile sperm domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017159.2 RefSeqGene

    Range
    5017..53923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177475.2NP_001170946.1  motile sperm domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001170946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC121340, AI744083, AK093075, AL834345
    UniProtKB/Swiss-Prot
    Q8NHP6
    Conserved Domains (2) summary
    pfam00635
    Location:264368
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:30171
    CRAL_TRIO; CRAL/TRIO domain
  2. NM_001330241.2NP_001317170.1  motile sperm domain-containing protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3'-terminal exon compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121340, AC140846
    Consensus CDS
    CCDS83457.1
    UniProtKB/TrEMBL
    R4GMN1
    Related
    ENSP00000473271.1, ENST00000482354.5
    Conserved Domains (2) summary
    pfam00635
    Location:327431
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:93234
    CRAL_TRIO; CRAL/TRIO domain
  3. NM_152581.4NP_689794.1  motile sperm domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_689794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC121340, AI744083, BC030641, DA708010
    Consensus CDS
    CCDS14162.1
    UniProtKB/Swiss-Prot
    Q8NA83, Q8NHP6
    Related
    ENSP00000369860.3, ENST00000380492.8
    Conserved Domains (2) summary
    pfam00635
    Location:327431
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam00650
    Location:93234
    CRAL_TRIO; CRAL/TRIO domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    14873421..14922327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    14453939..14503195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)