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CBLL2 Cbl proto-oncogene like 2 [ Homo sapiens (human) ]

Gene ID: 158506, updated on 5-Jan-2022

Summary

Official Symbol
CBLL2provided by HGNC
Official Full Name
Cbl proto-oncogene like 2provided by HGNC
Primary source
HGNC:HGNC:26371
See related
Ensembl:ENSG00000175809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT138; HAKAIL; ZNF645
Summary
This gene encodes a member of the zinc finger domain-containing protein family. This family member contains both a RING-type and a C2H2-type of zinc finger domain, and it may function as an E3 ubiquitin-protein ligase. Protein localization suggests a role in human sperm production and quality control. [provided by RefSeq, Aug 2011]
Orthologs
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Genomic context

See CBLL2 in Genome Data Viewer
Location:
Xp22.11
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (22272913..22274461)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (22291030..22292578)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene spermine synthase Neighboring gene phosphate regulating endopeptidase homolog X-linked Neighboring gene PHEX antisense RNA 1 Neighboring gene PTCHD1 antisense RNA (head to head) Neighboring gene methyltransferase like 15 pseudogene 3 Neighboring gene RNA, U6 small nuclear 266, pseudogene

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25735

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase CBLL2
Names
E3 ubiquitin ligase
E3 ubiquitin-protein ligase ZNF645
RING-type E3 ubiquitin transferase ZNF645
c-Cbl-like protein 2
cbl proto-oncogene-like protein 2
zinc finger protein 645
NP_689790.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021438.1 RefSeqGene

    Range
    4971..6519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152577.4NP_689790.1  E3 ubiquitin-protein ligase CBLL2

    See identical proteins and their annotated locations for NP_689790.1

    Status: REVIEWED

    Source sequence(s)
    BX293560
    Consensus CDS
    CCDS14205.1
    UniProtKB/Swiss-Prot
    Q8N7E2
    Related
    ENSP00000323348.2, ENST00000323684.4
    Conserved Domains (1) summary
    cd00162
    Location:57100
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    22272913..22274461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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