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TRMT10B tRNA methyltransferase 10B [ Homo sapiens (human) ]

Gene ID: 158234, updated on 7-Jun-2020

Summary

Official Symbol
TRMT10Bprovided by HGNC
Official Full Name
tRNA methyltransferase 10Bprovided by HGNC
Primary source
HGNC:HGNC:26454
See related
Ensembl:ENSG00000165275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RG9MTD3; bA3J10.9
Expression
Ubiquitous expression in endometrium (RPKM 2.9), brain (RPKM 2.7) and 25 other tissues See more
Orthologs

Genomic context

See TRMT10B in Genome Data Viewer
Location:
9p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (37753204..37780459)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37753797..37778969)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 1 Neighboring gene RAB1C, member RAS oncogene family pseudogene Neighboring gene RN7SK pseudogene 171 Neighboring gene uncharacterized LOC105376037 Neighboring gene exosome component 3 Neighboring gene DDB1 and CUL4 associated factor 10 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
tRNA (guanine(9)-N(1))-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (guanine-N1-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA (guanine-N1-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitochondrial tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tRNA methyltransferase 10 homolog B
Names
RNA (guanine-9-) methyltransferase domain containing 3
RNA (guanine-9-)-methyltransferase domain-containing protein 3
tRNA (guanine(9)-N(1))-methyltransferase TRMT10B
NP_001273879.1
NP_001273880.1
NP_001273881.1
NP_001273882.1
NP_001273883.1
NP_659401.2
XP_005251432.1
XP_005251436.1
XP_011516037.1
XP_011516038.1
XP_011516040.1
XP_011516041.1
XP_011516044.1
XP_011516045.1
XP_016869802.1
XP_024303194.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286950.1NP_001273879.1  tRNA methyltransferase 10 homolog B isoform b

    See identical proteins and their annotated locations for NP_001273879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK056017, AK092718, AK295733, CA440955, HY066525
    Consensus CDS
    CCDS69598.1
    UniProtKB/Swiss-Prot
    Q6PF06
    Related
    ENSP00000444997.1, ENST00000537911.5
    Conserved Domains (1) summary
    cl00407
    Location:144247
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  2. NM_001286951.1NP_001273880.1  tRNA methyltransferase 10 homolog B isoform c

    See identical proteins and their annotated locations for NP_001273880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, resulting in an alternate 5' UTR and translation initiation from an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK056017, AK092718, BC057774, CA440955, HY066525
    Consensus CDS
    CCDS69601.1
    UniProtKB/Swiss-Prot
    Q6PF06
    Related
    ENSP00000366983.2, ENST00000377754.6
    Conserved Domains (1) summary
    cl00407
    Location:41212
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  3. NM_001286952.1NP_001273881.1  tRNA methyltransferase 10 homolog B isoform d

    See identical proteins and their annotated locations for NP_001273881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, and it uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AK056017, AK092718, AK294219, BC057774, CA440955, HY066525
    Consensus CDS
    CCDS69600.1
    UniProtKB/Swiss-Prot
    Q6PF06
    Related
    ENSP00000366982.2, ENST00000377753.6
    Conserved Domains (1) summary
    cl00407
    Location:62220
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  4. NM_001286953.2NP_001273882.1  tRNA methyltransferase 10 homolog B isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, initiates translation from an alternate start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK056017, AK092718, AK315922, BC057774, CA440955, HY066525
    UniProtKB/Swiss-Prot
    Q6PF06
    UniProtKB/TrEMBL
    B7Z9F7
    Conserved Domains (1) summary
    cl00407
    Location:33187
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  5. NM_001286954.2NP_001273883.1  tRNA methyltransferase 10 homolog B isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an exon and uses an alternate splice site in the central region, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, and it uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (f) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK056017, AK092718, BC057774, CA440955, CR986760, HY066525
    UniProtKB/Swiss-Prot
    Q6PF06
    Conserved Domains (1) summary
    cl00407
    Location:84187
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  6. NM_144964.4NP_659401.2  tRNA methyltransferase 10 homolog B isoform a

    See identical proteins and their annotated locations for NP_659401.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK056017, AK092718, BC057774, CA440955, HY066525
    Consensus CDS
    CCDS43804.1
    UniProtKB/Swiss-Prot
    Q6PF06
    Related
    ENSP00000297994.3, ENST00000297994.4
    Conserved Domains (1) summary
    cl00407
    Location:136307
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase

RNA

  1. NR_104612.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK056017, AK092718, AK304516, BC057774, CA440955, HY066525

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    37753204..37780459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517743.2XP_011516045.1  tRNA methyltransferase 10 homolog B isoform X8

    See identical proteins and their annotated locations for XP_011516045.1

  2. XM_011517742.1XP_011516044.1  tRNA methyltransferase 10 homolog B isoform X8

    See identical proteins and their annotated locations for XP_011516044.1

    Related
    ENSP00000437395.1, ENST00000488673.6
  3. XM_017014313.2XP_016869802.1  tRNA methyltransferase 10 homolog B isoform X4

  4. XM_011517739.3XP_011516041.1  tRNA methyltransferase 10 homolog B isoform X6

    Conserved Domains (1) summary
    cl00407
    Location:75233
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  5. XM_011517736.3XP_011516038.1  tRNA methyltransferase 10 homolog B isoform X2

    Conserved Domains (1) summary
    cl00407
    Location:149311
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  6. XM_011517738.2XP_011516040.1  tRNA methyltransferase 10 homolog B isoform X5

    Conserved Domains (1) summary
    cl00407
    Location:75242
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  7. XM_011517735.3XP_011516037.1  tRNA methyltransferase 10 homolog B isoform X1

    Conserved Domains (1) summary
    cl00407
    Location:149320
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  8. XM_024447426.1XP_024303194.1  tRNA methyltransferase 10 homolog B isoform X3

    Conserved Domains (1) summary
    cl00407
    Location:136298
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  9. XM_005251379.2XP_005251436.1  tRNA methyltransferase 10 homolog B isoform X9

    Conserved Domains (1) summary
    cl00407
    Location:4175
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
  10. XM_005251375.2XP_005251432.1  tRNA methyltransferase 10 homolog B isoform X7

    Conserved Domains (1) summary
    cl00407
    Location:62229
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase

RNA

  1. XR_001746191.2 RNA Sequence

  2. XR_001746192.1 RNA Sequence

  3. XR_929185.2 RNA Sequence

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