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TTLL11 tubulin tyrosine ligase like 11 [ Homo sapiens (human) ]

Gene ID: 158135, updated on 25-Nov-2021

Summary

Official Symbol
TTLL11provided by HGNC
Official Full Name
tubulin tyrosine ligase like 11provided by HGNC
Primary source
HGNC:HGNC:18113
See related
Ensembl:ENSG00000175764 Ensembl:ENSG00000237548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf20; C9orf148; TTLL11-IT1; bA244O19.1
Expression
Ubiquitous expression in brain (RPKM 2.0), testis (RPKM 1.0) and 25 other tissues See more
Orthologs
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Genomic context

See TTLL11 in Genome Data Viewer
Location:
9q33.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (121815674..122093418, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (124577953..124855587, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene DAB2 interacting protein Neighboring gene uncharacterized LOC105376257 Neighboring gene uncharacterized LOC107987125 Neighboring gene Sharpr-MPRA regulatory region 3979 Neighboring gene microRNA 4478 Neighboring gene NADH:ubiquinone oxidoreductase subunit A8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available
Genome-wide association study of periodontal pathogen colonization.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin-glutamic acid ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tubulin-glutamic acid ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule severing IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyglutamylation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tubulin polyglutamylase TTLL11
Names
TTLL11 intronic transcript 1
TTLL11 intronic transcript 1 (non-protein coding)
tubulin tyrosine ligase like11
tubulin tyrosine ligase-like family, member 11
tubulin--tyrosine ligase-like protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139442.2NP_001132914.2  tubulin polyglutamylase TTLL11 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL162423, AL442634, AL445587, AL596244
    Consensus CDS
    CCDS48012.1
    Related
    ENSP00000321346.6, ENST00000321582.11
    Conserved Domains (1) summary
    cl17255
    Location:181482
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
  2. NM_001386831.1NP_001373760.1  tubulin polyglutamylase TTLL11 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL162423, AL442634, AL445587
    Conserved Domains (1) summary
    cl17255
    Location:181482
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
  3. NM_001386832.1NP_001373761.1  tubulin polyglutamylase TTLL11 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL445587
  4. NM_001386833.1NP_001373762.1  tubulin polyglutamylase TTLL11 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL445587, AL596244
  5. NM_194252.3NP_919228.3  tubulin polyglutamylase TTLL11 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF521886, AL445587
    Consensus CDS
    CCDS6834.2
    Related
    ENSP00000362881.4, ENST00000373776.5
    Conserved Domains (1) summary
    cl17255
    Location:181423
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

RNA

  1. NR_171569.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445587
    Related
    ENST00000411790.1
  2. NR_171570.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445587

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    121815674..122093418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251728.2XP_005251785.1  tubulin polyglutamylase TTLL11 isoform X4

    Conserved Domains (1) summary
    cl17255
    Location:12249
    ATP-grasp_4; ATP-grasp domain
  2. XM_005251729.4XP_005251786.1  tubulin polyglutamylase TTLL11 isoform X3

    Conserved Domains (1) summary
    cl17255
    Location:1295
    ATP-grasp_4; ATP-grasp domain
  3. XM_017014309.2XP_016869798.1  tubulin polyglutamylase TTLL11 isoform X2

RNA

  1. XR_001746188.1 RNA Sequence

  2. XR_001746189.2 RNA Sequence

  3. XR_929721.3 RNA Sequence

  4. XR_929720.3 RNA Sequence

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