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AK8 adenylate kinase 8 [ Homo sapiens (human) ]

Gene ID: 158067, updated on 9-Jul-2021

Summary

Official Symbol
AK8provided by HGNC
Official Full Name
adenylate kinase 8provided by HGNC
Primary source
HGNC:HGNC:26526
See related
Ensembl:ENSG00000165695 MIM:615365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AK 8; DDX31; C9orf98
Expression
Biased expression in testis (RPKM 3.3), thyroid (RPKM 0.7) and 8 other tissues See more
Orthologs
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Genomic context

See AK8 in Genome Data Viewer
Location:
9q34.13
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (132725574..132879046, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135600965..135754433, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene BarH like homeobox 1 Neighboring gene DEAD-box helicase 31 Neighboring gene general transcription factor IIIC subunit 4 Neighboring gene Sharpr-MPRA regulatory region 7884 Neighboring gene sperm acrosome associated 9 Neighboring gene TSC complex subunit 1 Neighboring gene microRNA 548aw Neighboring gene growth factor independent 1B transcriptional repressor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
GeneReviews: Not available
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32704, FLJ36014

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytidylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in 9+2 motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in axoneme IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in sperm flagellum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenylate kinase 8
Names
ATP-AMP transphosphorylase 8
putative adenylate kinase-like protein C9orf98
NP_001304887.1
NP_001304888.1
NP_001358700.1
NP_001358701.1
NP_001358702.1
NP_001358703.1
NP_689785.1
XP_005272226.1
XP_006717028.1
XP_011516579.1
XP_011516580.1
XP_016869797.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317958.2NP_001304887.1  adenylate kinase 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL160165, AL445645
    UniProtKB/Swiss-Prot
    Q96MA6
    Conserved Domains (1) summary
    cd01428
    Location:66258
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  2. NM_001317959.2NP_001304888.1  adenylate kinase 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL160165, AL445645
    UniProtKB/Swiss-Prot
    Q96MA6
    Related
    ENST00000477396.5
    Conserved Domains (2) summary
    cd01428
    Location:98290
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:98296
    adk; adenylate kinase
  3. NM_001371771.1NP_001358700.1  adenylate kinase 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL160165, AL445645
    Conserved Domains (1) summary
    cd01428
    Location:241433
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  4. NM_001371772.1NP_001358701.1  adenylate kinase 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL160165, AL445645
    Conserved Domains (2) summary
    PLN02842
    Location:58205
    PLN02842; nucleotide kinase
    cd01428
    Location:225417
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  5. NM_001371773.1NP_001358702.1  adenylate kinase 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL160165, AL445645
    Conserved Domains (1) summary
    cd01428
    Location:66258
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  6. NM_001371774.1NP_001358703.1  adenylate kinase 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL160165, AL445645
    Conserved Domains (1) summary
    cd01428
    Location:66258
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  7. NM_152572.3NP_689785.1  adenylate kinase 8 isoform 1

    See identical proteins and their annotated locations for NP_689785.1

    Status: VALIDATED

    Source sequence(s)
    AL160165, AL445645
    Consensus CDS
    CCDS6954.1
    UniProtKB/Swiss-Prot
    Q96MA6
    Related
    ENSP00000298545.3, ENST00000298545.4
    Conserved Domains (1) summary
    cd01428
    Location:270462
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    132725574..132879046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272169.2XP_005272226.1  adenylate kinase 8 isoform X1

    Conserved Domains (2) summary
    cd01428
    Location:282474
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:282480
    adk; adenylate kinase
  2. XM_011518278.2XP_011516580.1  adenylate kinase 8 isoform X3

    Conserved Domains (2) summary
    cd01428
    Location:196388
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:196394
    adk; adenylate kinase
  3. XM_006716965.2XP_006717028.1  adenylate kinase 8 isoform X2

    Conserved Domains (2) summary
    cd01428
    Location:198390
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:198396
    adk; adenylate kinase
  4. XM_017014308.1XP_016869797.1  adenylate kinase 8 isoform X5

    Conserved Domains (2) summary
    cd01428
    Location:98290
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:98296
    adk; adenylate kinase
  5. XM_011518277.2XP_011516579.1  adenylate kinase 8 isoform X4

    Conserved Domains (3) summary
    cd01428
    Location:71261
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:71270
    adk; adenylate kinase
    cl17190
    Location:282335
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RNA

  1. XR_929719.2 RNA Sequence

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