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NXNL2 nucleoredoxin like 2 [ Homo sapiens (human) ]

Gene ID: 158046, updated on 1-Jun-2020

Summary

Official Symbol
NXNL2provided by HGNC
Official Full Name
nucleoredoxin like 2provided by HGNC
Primary source
HGNC:HGNC:30482
See related
Ensembl:ENSG00000130045 MIM:615299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDCVF2; RdCVF2L; C9orf121
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See NXNL2 in Genome Data Viewer
Location:
9q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (88535088..88584510)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91149203..91190704)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 85 Neighboring gene uncharacterized LOC105376134 Neighboring gene long intergenic non-protein coding RNA 2843 Neighboring gene uncharacterized LOC105376135 Neighboring gene microRNA 4289

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleoredoxin-like 2 (NXNL2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
photoreceptor cell maintenance IEA
Inferred from Electronic Annotation
more info
 
sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
visual perception IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nucleoredoxin-like protein 2
Names
rod-derived cone viability factor 2
NP_001155097.1
NP_660326.2
XP_005251784.1
XP_011516577.1
XP_011516578.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161625.1NP_001155097.1  nucleoredoxin-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001155097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL162729
    Consensus CDS
    CCDS55325.1
    UniProtKB/Swiss-Prot
    Q5VZ03
    Related
    ENSP00000365014.3, ENST00000375854.7
    Conserved Domains (1) summary
    cd02964
    Location:10144
    TryX_like_family; Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are ...
  2. NM_145283.3NP_660326.2  nucleoredoxin-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL162729, AL592486, BC022521
    Consensus CDS
    CCDS6679.1
    UniProtKB/Swiss-Prot
    Q5VZ03
    Related
    ENSP00000365015.3, ENST00000375855.3
    Conserved Domains (1) summary
    cl00388
    Location:10104
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    88535088..88584510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518276.2XP_011516578.1  nucleoredoxin-like protein 2 isoform X2

    Conserved Domains (1) summary
    cl00388
    Location:10103
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_005251727.3XP_005251784.1  nucleoredoxin-like protein 2 isoform X3

    Conserved Domains (1) summary
    cl00388
    Location:10101
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. XM_011518275.2XP_011516577.1  nucleoredoxin-like protein 2 isoform X1

    Conserved Domains (1) summary
    cd02964
    Location:10196
    TryX_like_family; Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are ...

RNA

  1. XR_001746187.1 RNA Sequence

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