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NXNL2 nucleoredoxin like 2 [ Homo sapiens (human) ]

Gene ID: 158046, updated on 5-Mar-2024

Summary

Official Symbol
NXNL2provided by HGNC
Official Full Name
nucleoredoxin like 2provided by HGNC
Primary source
HGNC:HGNC:30482
See related
Ensembl:ENSG00000130045 MIM:615299; AllianceGenome:HGNC:30482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDCVF2; RdCVF2L; C9orf121
Summary
Predicted to be involved in photoreceptor cell maintenance and sensory perception. Predicted to act upstream of or within sensory perception of smell and visual perception. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NXNL2 in Genome Data Viewer
Location:
9q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (88535178..88584510)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (100689280..100738616)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91150093..91190708)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:91110399-91110940 Neighboring gene ribosomal protein L21 pseudogene 85 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:91134584-91135288 Neighboring gene uncharacterized LOC105376134 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:91149879-91150713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:91150714-91151547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91204313-91204818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:91240150-91240802 Neighboring gene long intergenic non-protein coding RNA 2843 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:91266744-91267943 Neighboring gene uncharacterized LOC105376135 Neighboring gene microRNA 4289

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleoredoxin-like 2 (NXNL2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
nucleoredoxin-like protein 2
Names
rod-derived cone viability factor 2
NP_001155097.1
NP_660326.2
XP_005251784.1
XP_011516578.1
XP_054189057.1
XP_054189058.1
XP_054189059.1
XP_054218027.1
XP_054218028.1
XP_054218029.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161625.2NP_001155097.1  nucleoredoxin-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001155097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL162729
    Consensus CDS
    CCDS55325.1
    UniProtKB/Swiss-Prot
    B1AMD0, Q5VZ03, Q8TBG6
    Related
    ENSP00000365014.3, ENST00000375854.8
    Conserved Domains (1) summary
    cd02964
    Location:10144
    TryX_like_family; Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are ...
  2. NM_145283.3NP_660326.2  nucleoredoxin-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL162729, AL592486, BC022521
    Consensus CDS
    CCDS6679.1
    UniProtKB/Swiss-Prot
    Q5VZ03
    Related
    ENSP00000365015.3, ENST00000375855.3
    Conserved Domains (1) summary
    cl00388
    Location:10104
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    88535178..88584510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518276.3XP_011516578.1  nucleoredoxin-like protein 2 isoform X1

    Conserved Domains (1) summary
    cl00388
    Location:10103
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_005251727.4XP_005251784.1  nucleoredoxin-like protein 2 isoform X2

    Conserved Domains (1) summary
    cl00388
    Location:10101
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791787.1 Reference GRCh38.p14 PATCHES

    Range
    15723..65055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333083.1XP_054189058.1  nucleoredoxin-like protein 2 isoform X1

  2. XM_054333084.1XP_054189059.1  nucleoredoxin-like protein 2 isoform X2

  3. XM_054333082.1XP_054189057.1  nucleoredoxin-like protein 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    100689280..100738616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362053.1XP_054218028.1  nucleoredoxin-like protein 2 isoform X1

  2. XM_054362054.1XP_054218029.1  nucleoredoxin-like protein 2 isoform X2

  3. XM_054362052.1XP_054218027.1  nucleoredoxin-like protein 2 isoform X4