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NKX6-3 NK6 homeobox 3 [ Homo sapiens (human) ]

Gene ID: 157848, updated on 17-Jun-2024

Summary

Official Symbol
NKX6-3provided by HGNC
Official Full Name
NK6 homeobox 3provided by HGNC
Primary source
HGNC:HGNC:26328
See related
Ensembl:ENSG00000165066 MIM:610772; AllianceGenome:HGNC:26328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKX6.3
Summary
The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in stomach (RPKM 15.7) and duodenum (RPKM 4.5) See more
Orthologs
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Genomic context

See NKX6-3 in Genome Data Viewer
Location:
8p11.21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (41645177..41650817, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (41918807..41924450, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41502696..41508336, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene GPAT4 and GINS4 antisense RNA 1 Neighboring gene uncharacterized LOC124901939 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41424977-41425739 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:41430689-41430895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41451733-41452234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41454165-41454665 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:41466108-41467307 Neighboring gene glycerol-3-phosphate acyltransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41510853-41511646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41513473-41514006 Neighboring gene microRNA 486-1 Neighboring gene microRNA 486-2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:41541049-41542248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41543347-41543848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41543849-41544348 Neighboring gene ankyrin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27293 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:41570734-41571933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41574438-41575290 Neighboring gene Sharpr-MPRA regulatory region 1462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41591757-41592299 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:41592277-41593476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41593686-41594662 Neighboring gene Sharpr-MPRA regulatory region 338 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:41649575-41650774 Neighboring gene uncharacterized LOC105379392 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:41656213-41657412

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25169

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
homeobox protein Nkx-6.3
Names
NK6 transcription factor related, locus 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364841.2NP_001351770.1  homeobox protein Nkx-6.3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009630, AC113133
    Consensus CDS
    CCDS94289.1
    UniProtKB/Swiss-Prot
    A6NJ46, Q96LR0
    Related
    ENSP00000428361.2, ENST00000518699.4
    Conserved Domains (1) summary
    pfam00046
    Location:142195
    Homeobox; Homeobox domain
  2. NM_152568.3NP_689781.1  homeobox protein Nkx-6.3 isoform 2

    See identical proteins and their annotated locations for NP_689781.1

    Status: VALIDATED

    Source sequence(s)
    AC009630, AK057898
    Consensus CDS
    CCDS6118.1
    UniProtKB/Swiss-Prot
    A6NJ46
    Related
    ENSP00000429553.2, ENST00000524115.2
    Conserved Domains (1) summary
    cl00084
    Location:5566
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    41645177..41650817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    41918807..41924450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)